Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Gravin / AKAP12 antibody was raised against synthetic peptide C-SPDTNGPKLTEEGD from an internal region of mouse AKAP12 (NP_112462.1). Percent identity by BLAST analysis: Mouse, Rat (100%).
LS-E27711 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C139806. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Mouse AKAP12. This antibody is expected to recognize isoform 1 (NP_005091.2) only.
Peptide ELISA: antibody detection limit dilution 1:4000. Western blot: Preliminary experiments in lysates of cell lines NIH3T3 and of Mouse and Rat Brain and Testis gave no specific signal but low background (at antibody concentration up to 2 ug/ml).
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells.