Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Mouse, Rat, Hamster (tested or 100% immunogen sequence identity)
Bovine, Dog (at least 90% immunogen sequence identity)
Western blot (1:32000) & (0.3 - 1 µg/ml)
IHC - Paraffin
Specificity and Use
GRAP antibody was raised against synthetic peptide C-GFFPRSYVQPVHL from the C-terminus of human GRAP (NP_006604.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Mouse, Rat, Hamster (100%); Panda, Dog, Bovine (92%); Marmoset, Opossum, Platypus (85%).
LS-E25222 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C54941. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
GRAP Antibody, GRB2-related adaptor protein Antibody, GRB2-related adapter protein Antibody
GRAP is a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.