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Anti-GPR49 / LGR5 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1236

Catalog Size Price
LS-A1236-50 50 µg (1 mg/ml) Unavailable
Same day shipping In Stock - Same day shipping

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38 GPR49 / LGR5 Antibodies

Most Popular GPR49 / LGR5 Antibodies

Anti-GPR49 / LGR5 Antibody (aa689-719) LS-C98619
Rabbit Polyclonal to Human GPR49 / LGR5
Immunofluorescence, Western blot, Flow Cytometry
Fluorescent confocal image of HeLa cells stained with LGR5 (loop2) antibody. HeLa cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated LGR5 (loop2) primary antibody (1:100, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 ug/ml, 5 min). Note the highly specific localization of the LGR5 immunosignal to the nucleus and cytoplasm, supported by Human Protein Atlas Data (
Anti-GPR49 / LGR5 Antibody (aa650-700) LS-C143162
Rabbit Polyclonal to Human GPR49 / LGR5
IHC - Paraffin, Western blot
GPR49 Antibody (LGR5) - IHC of human small intestine using GPR49.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-GPR49 / LGR5 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1236
Rabbit Polyclonal to Human GPR49 / LGR5
IHC - Paraffin, Immunofluorescence
Human, Small Intestine: Formalin-Fixed Paraffin-Embedded (FFPE)
Anti-GPR49 / LGR5 Antibody (N-Terminus) IHC-plus™ LS-A1232
Rabbit Polyclonal to Human GPR49 / LGR5
Human, Monkey, Bat
IHC - Paraffin, ICC, Immunofluorescence
Human, Pancreas, Islets: Formalin-Fixed Paraffin-Embedded (FFPE)
Anti-GPR49 / LGR5 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1235
Rabbit Polyclonal to Human GPR49 / LGR5
IHC - Paraffin
Human, Brain, neurons: Formalin-Fixed Paraffin-Embedded (FFPE)

100% Guaranteed In Stock Publications (3)
Rabbit Polyclonal to Human GPR49 / LGR5
IHC - Paraffin, Immunofluorescence


Human GPR49 / LGR5
Human (tested or 100% immunogen sequence identity)
Monkey, Bat, Bovine, Hamster, Rabbit (at least 90% immunogen sequence identity)
Immunoaffinity purified


  • IHC - Paraffin (5 µg/ml)
  • Immunofluorescence

Specificity and Use

GPR49 / LGR5 antibody was raised against synthetic 20 amino acid peptide from 1st cytoplasmic domain of human GPR49 / LGR5. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%); Marmoset, Bovine, Bat (95%); Hamster, Elephant, Panda, Rabbit (90%); Mouse, Rat, Opossum (85%).
LS-E28194 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A1236. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Cytoplasmic Domain
Human GPR49 / LGR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.


PBS, 10% glycerol, 0.09% sodium azide
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles.
For research use only.

Publications (3)

Expression of the adult intestinal stem cell marker Lgr5 in the metastatic cascade of colorectal cancer. Kleist B, Xu L, Li G, Kersten C. International journal of clinical and experimental pathology. 2011 4:327-35. (IHC-P; Human) [Full Text Article] [PubMed:21577318] [PMC:PMC3093057]
EP receptor expression in human intestinal epithelium and localization relative to the stem cell zone of the crypts. Olsen Hult LT, Kleiveland CR, Fosnes K, Jacobsen M, Lea T. PloS one. 2011 6:e26816. (ICC, IHC-P; Human) [Full Text Article] [PubMed:22046368] [PMC:PMC3201980]
Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. Chen QQ, Yan L, Wang CZ, Wang WH, Shi H, Su BB, Zeng QH, Du HT, Wan J. World journal of gastroenterology : WJG. 2013 Aug;19:4702-17. [Full Text Article] [PubMed:23922467] [PMC:PMC3732842]

About GPR49 / LGR5

O75473 NM_003667 NP_003658.1

LGR5 Antibody, FEX Antibody, G-protein coupled receptor 49 Antibody, G protein-coupled receptor 49 Antibody, GPR67 Antibody, GRP49 Antibody, GPR49 Antibody, HG38 Antibody, G-protein coupled receptor 67 Antibody

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.


Human, Small Intestine: Formalin-Fixed Paraffin-Embedded (FFPE)
Human, Small Intestine: Formalin-Fixed Paraffin-Embedded (FFPE)


Human Colon: Formalin-Fixed Paraffin-Embedded (FFPE)
Human Colon: Formalin-Fixed Paraffin-Embedded (FFPE)

Requested From: 
Date Requested: 4/19/2018

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