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Anti-GPER1 / GPR30 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1183

Ordering

Wt. Vol. Conc. Price
50 µg 50 µl 1 mg/ml Unavailable
Same day shipping In Stock - Same day shipping

Related Products

35 GPER1 / GPR30 Antibodies

Most Popular GPER1 / GPR30 Antibodies

Anti-GPER1 / GPR30 Antibody (Extracellular Domain) IHC-plus™ LS-A1184
Rabbit Polyclonal to Human GPER1 / GPR30
Human
IHC - Paraffin, Immunofluorescence
Unconjugated
Immunohistochemistry Image
Anti-GPER1 / GPR30 Antibody (Extracellular Domain) IHC-plus™ LS-A4271
Rabbit Polyclonal to Human GPER1 / GPR30
Human, Monkey
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated
Immunohistochemistry Image
Anti-GPER1 / GPR30 Antibody (C-Terminus) IHC-plus™ LS-A4272
Rabbit Polyclonal to Human GPER1 / GPR30
Human, Monkey, Dog
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated
Immunohistochemistry Image
Anti-GPER1 / GPR30 Antibody (N-Terminus) IHC-plus™ LS-A4290
Rabbit Polyclonal to Human GPER1 / GPR30
Human
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated
Immunohistochemistry Image
Anti-GPER1 / GPR30 Antibody (aa357-370) IHC-plus™ LS-B5132
Goat Polyclonal to Human GPER1 / GPR30
Human, Monkey, Dog
IHC - Paraffin
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed In Stock In Stock Publications Publications (4)
Rabbit Polyclonal to Human GPER1 / GPR30
Human
IHC - Paraffin, Western blot
Unconjugated

Details

Human GPER1 / GPR30
Rabbit
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (15 - 20 µg/ml)
  • Western blot

  • Immunofluorescence

Specificity and Use

GPER1 / GPR30 antibody was raised against synthetic 16 amino acid peptide from 1st cytoplasmic domain of human GPR30. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Marmoset (94%); Monkey, Panda (88%).
LS-E28164 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A1183. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Cytoplasmic Domain
Human GPR30. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Packaging

PBS, less than 0.1% sodium azide.
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles.
For research use only.

Publications (4)

1
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Thomas P, Pang Y, Filardo EJ and Dong J. Endocrinology. 2005 146:624-32. (ICC; Human) [PubMed:15539556]
2
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, Andò S and Maggiolini M. Molecular endocrinology (Baltimore, Md.). 2006 20:631-46. (WB; Human) [PubMed:16239258] [PMC:PMC3060528]
3
Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. Pandey DP, Lappano R, Albanito L, Madeo A, Maggiolini M, Picard D. The EMBO journal. 2009 28:523-32. (WB; Human) [Full Text Article] [PubMed:19153601] [PMC:PMC2657575]
4
Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine and analogs of gonadotropin-releasing hormoneI andII to overcome tamoxifen resistance in breast cancer cells. Block M, Gr[Character fc]ndker C, Fister S, Kubin J, Wilkens L, Mueller MD, Hemmerlein B, Emons G, G[Character fc]nthert AR. International journal of oncology. 2012 Nov;41:1845-54. [Full Text Article] [PubMed:22922893]
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About GPER1 / GPR30

Q99527 NM_001505 NP_001496.1

GPER1 Antibody, CMKRL2 Antibody, CEPR Antibody, FEG-1 Antibody, G-protein coupled receptor 30 Antibody, G protein-coupled receptor 30 Antibody, GPCR-Br Antibody, GPER Antibody, Heptahelix receptor Antibody, LERGU Antibody, LyGPR Antibody, MER Antibody, GPR30 Antibody, IL8-related receptor DRY12 Antibody, LERGU2 Antibody, Chemokine receptor-like 2 Antibody, DRY12 Antibody, Membrane estrogen receptor Antibody

G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK.

Immunohistochemistry

Immunohistochemistry
Anti-GPER1 / GPR30 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Immunohistochemistry
Anti-GPER1 / GPR30 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Immunohistochemistry
Human, Pancreas, Islet: Formalin-Fixed Paraffin-Embedded (FFPE)

Immunohistochemistry

Immunohistochemistry
Anti-GPER1 / GPR30 antibody IHC of human breast, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Immunohistochemistry
Anti-GPER1 / GPR30 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Immunohistochemistry
Anti-GPER1 / GPR30 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Requested From: 
Date Requested: 4/25/2017

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