Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Connexin 43 controls the multipolar phase of neuronal migration to the cerebral cortex. Liu X, Sun L, Torii M, Rakic P. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:8280-5.
GJA1 Antibody, Connexin-43 Antibody, DFNB38 Antibody, Connexin 43 Antibody, Gap junction alpha-1 protein Antibody, GJAL Antibody, HSS Antibody, Gap junction protein alpha 1 Antibody, ODDD Antibody, ODD Antibody, AVSD3 Antibody, CX43 Antibody, HLHS1 Antibody, ODOD Antibody, SDTY3 Antibody
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of lysates from HeLa, U-87 MG, C6 cell line and mouse heart tissue lysate (from left to right), using GJA1 Antibody (N121). Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
(LEFT)Western blot of anti-GJA1 Antibody in CEM cell line lysates (35 ug/lane). GJA1(arrow) was detected using the purified antibody.(RIGHT)Western blot of hGJA1-N121.Connexin in mouse brain tissue lysates (35 ug/lane). GJA1 (arrow) was detected using the purified antibody.