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GJA1 / CX43 / Connexin 43

gap junction protein, alpha 1, 43kDa

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract.

Gene Name: gap junction protein, alpha 1, 43kDa
Family/Subfamily: Ion Channel , Connexin
Synonyms: GJA1, Connexin-43, DFNB38, Connexin 43, Gap junction alpha-1 protein, GJAL, HSS, Gap junction protein alpha 1, ODDD, ODD, AVSD3, CX43, HLHS1, ODOD, SDTY3
Target Sequences: NM_000165 NP_000156.1 P17302

Publications (3)

1
Connexin 43 controls the multipolar phase of neuronal migration to the cerebral cortex. Liu X, Sun L, Torii M, Rakic P. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:8280-5. [PubMed:22566616] [PMC:PMC3361458] Related Antibodies: LS-C97725.
2
Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice. Yang H, Yan H, Li X, Liu J, Cao S, Huang B, Huang D, Wu L. Frontiers in cellular neuroscience. 2018 May;12:129. (Rat) [Full Text Article] [PubMed:29867362] [PMC:PMC5951934] Related Antibodies: LS-B9771.
3
Structural alterations and inflammation in the heart after multiple trauma followed by reamed versus non-reamed femoral nailing. Meike Baur, Birte Weber, Ina Lackner, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Michel Teuben, Miriam Lipiski, Nikola Cesarovic, Hans-Christoph Pape, Miriam Kalbitz. PloS one. 2020 June;15:e0235220. [Full Text Article] [PubMed:32584885] [PMC:PMC7316303]

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Products
Antibodies (145)
Primary (145)
GJA1 / CX43 / Connexin 43 (145)
Human (127)
Mouse (105)
Rat (90)
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Crab-eating macaque (1)
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IP (4)
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rabbit (119)
mouse (23)
goat (3)
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IgG (58)
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monoclonal mc (23)
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Unconjugated (74)
aa180-382 (24)
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aa107-138 (8)
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200-280 aa (2)
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2nd Cytoplasmic Domain (1)
310-390 aa, C-terminal (1)
Ab-261 (1)
Arg361 (1)
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aa226-275 (1)
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aa333-346 (1)
aa333-382 (1)
aa340-390 (1)
aa351-367 (1)
p367 (1)
pSer262 (1)
pSer265 (1)
No (143)
Yes (2)
GJA1 / CX43 / Connexin 43 Antibody - Anti-GJA1 / CX43 / Connexin 43 antibody IHC staining of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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GJA1 / CX43 / Connexin 43 Goat anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µg/$440
GJA1 / CX43 / Connexin 43 Antibody - Anti-GJA1 / CX43 / Connexin 43 antibody IHC staining of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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GJA1 / CX43 / Connexin 43 Goat anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
GJA1 / CX43 / Connexin 43 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
GJA1 / CX43 / Connexin 43 Antibody - Anti-GJA1 / Connexin 43 antibody IHC of human testis, seminiferous tubules and Leydig cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (aa107-138) (PE) Antibody
Human
ELISA, IHC, IHC-P, WB
PE Conjugated
200 µl/$871
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (aa107-138) (AP) Antibody
Human
ELISA, IHC, IHC-P, WB
AP Conjugated
200 µl/$871
GJA1 / CX43 / Connexin 43 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (aa107-138) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$396
GJA1 / CX43 / Connexin 43 Antibody - Anti-GJA1 / CX43 / Connexin 43 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (aa340-390) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
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GJA1 / CX43 / Connexin 43 Mouse anti-Mouse Monoclonal (aa252-270) Antibody
Mouse, Dog, Rat, Pig, Human
ELISA, ICC, IHC, IHC-Fr, WB
Unconjugated
100 µg/$763
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GJA1 / CX43 / Connexin 43 Mouse anti-Mouse Monoclonal (PE) Antibody
Mouse, Rat, Pig, Human
ELISA, ICC, IHC, WB
PE Conjugated
100 µl/$919
GJA1 / CX43 / Connexin 43 Antibody - Antibody (0.3 ug/ml) staining of Rat Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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GJA1 / CX43 / Connexin 43 Goat anti-Human Polyclonal (aa333-346) Antibody
Rabbit, Dog, Guinea pig, Rat, Pig, Bat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$467
GJA1 / CX43 / Connexin 43 Antibody - IHC of Connexin 43 (K257) pAb in paraffin-embedded human brain tissue.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (Lys257) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$404
GJA1 / CX43 / Connexin 43 Antibody - Anti-GJA1 / Connexin 43 antibody IHC of human seminiferous tubule and Leydig cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Human
IHC, IHC-P
Unconjugated
50 µg/$460
GJA1 / CX43 / Connexin 43 Antibody - Anti-GJA1 / Connexin 43 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (aa333-382) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (pTyr265) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$289; 100 µl/$319; 200 µl/$389
GJA1 / CX43 / Connexin 43 Antibody - Connexin 43/GJA1 antibody IHC-paraffin: Human Lung Cancer Tissue.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (aa351-367) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$431
GJA1 / CX43 / Connexin 43 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Connexin 43 (Phospho-Ser367) Antibody. The picture on the right is blocked with the phospho peptide.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (pSer367) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$328; 100 µl/$388
GJA1 / CX43 / Connexin 43 Antibody - Western blot of Phospho-Connexin 43 (S368) antibody
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (300-380 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$289; 100 µl/$319; 200 µl/$389
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GJA1 / CX43 / Connexin 43 Mouse anti-Rat Monoclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$813
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GJA1 / CX43 / Connexin 43 Mouse anti-Rat Monoclonal (PE) Antibody
Mouse, Dog, Rat, Human
ELISA, IF, WB
PE Conjugated
100 µl/$952
GJA1 / CX43 / Connexin 43 Antibody - 1:100 staining human thyroid carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal (pTyr265) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
GJA1 / CX43 / Connexin 43 Antibody - Western blot of Connexin 43 expression in PMA treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µg/$305; 100 µg/$357
GJA1 / CX43 / Connexin 43 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human brain tissue using Connexin 43 antibody.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
GJA1 / CX43 / Connexin 43 Antibody - Western blot of HUVEC cell lysate using Connexin 43 Antibody
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
GJA1 / CX43 / Connexin 43 Antibody - 1:200 staining human kidney tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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GJA1 / CX43 / Connexin 43 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).