Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 3G7] (IgG2b,k) to Human FZD4 / Frizzled 4
Western blot, ELISA
Goat Polyclonal to Human FZD4 / Frizzled 4
Human, Monkey, Bat, Bovine, Dog, Horse, Rabbit, Xenopus
Western blot, ELISA
Human FZD4 / Frizzled 4
Human, Monkey, Bat, Bovine, Dog, Horse, Rabbit, Xenopus (tested or 100% immunogen sequence identity)
Mouse, Rat (at least 90% immunogen sequence identity)
Western blot (0.3 - 1 µg/ml)
IHC - Paraffin
Specificity and Use
Synthetic peptide DEEERRCDPIRIS from an internal region of human FZD4 / Frizzled 4 (NP_036325.2). Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Panda, Dog, Bovine, Bat, Horse, Rabbit, Opossum, Xenopus (100%); Mouse, Rat, Elephant, Lizard (92%); Chicken, Zebrafish (85%).
LS-E26628 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C61739. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP).