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FN1 / Fibronectin

fibronectin 1

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Gene Name: fibronectin 1
Synonyms: FN1, CIG, Cold-insoluble globulin, Fibronectin 1, FINC, LETS, GFND, ED-B, Fibronectin, FN, FNZ, GFND2, Migration-stimulating factor, MSF
Target Sequences: NM_002026 NP_002017.1 P02751

Publications (5)

1
Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes. Xinlei Li, Ruju Chen, Sherri Kemper, David R Brigstock. Frontiers in cell and developmental biology. 2021 Mar;9:640667. [Full Text Article] [PubMed:33816490] [PMC:PMC8012540]
2
Interventricular Differences of Signaling Pathways-Mediated Regulation of Cardiomyocyte Function in Response to High Oxidative Stress in the Post-Ischemic Failing Rat Heart. Árpád Kovács , Melissa Herwig , Heidi Budde , Simin Delalat , Detmar Kolijn , Beáta Bódi, Roua Hassoun , Melina Tangos , Saltanat Zhazykbayeva , Ágnes Balogh, Dániel Czuriga, Sophie Van Linthout, Carsten Tschöpe, Naranjan S Dhalla, Andreas Mügge , Attila Tóth , Zoltán Papp , Judit Barta, Nazha Hamdani. Antioxidants. 2021 Jun;10:964. [Full Text Article] [PubMed:34208541] [PMC:PMC8234177]
3
Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats. Edwin K Jackson, Zaichuan Mi, Delbert G Gillespie, Dongmei Cheng, Stevan P Tofovic. Journal of the American Heart Association. 2021 March;10:e020088. [Full Text Article] [PubMed:33682436] [PMC:PMC8174220]
4
Decellularization alters the unfavorable regenerative adverse microenvironment of the injured spinal cord to support neurite outgrowth. Junxia Hu , Jianghong Shangguan , Parizat Askar, Jinghui Xu, Hualin Sun, Songlin Zhou, Changlai Zhu, Wenfeng Su, Yun Gu. Annals of translational medicine. 2022 September;10:934. [Full Text Article] [PubMed:36172103] [PMC:PMC9511201]
5
Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease. Carlotta Mayer, Sophie Nehring, Michael Kücken, Urska Repnik, Sarah Seifert, Aleksandra Sljukic, Julien Delpierre, Hernán Morales-Navarrete, Sebastian Hinz, Mario Brosch, Brian Chung, Tom Karlsen, Meritxell Huch, Yannis Kalaidzidis, Lutz Brusch, Jochen Hampe, Clemens Schafmayer, Marino Zerial. EMBO reports. 2023 September;24:e57181. [Full Text Article] [PubMed:37522754] [PMC:PMC10592352]
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FN1 / Fibronectin Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FN1 / Fibronectin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$525
FN1 / Fibronectin Antibody - Anti-FN1 / Fibronectin antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 25 ug/ml.
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FN1 / Fibronectin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$515
FN1 / Fibronectin Antibody - Immunohistochemical analysis of Fibronectin staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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FN1 / Fibronectin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
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FN1 / Fibronectin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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FN1 / Fibronectin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
1 mg/$594
FN1 / Fibronectin Antibody - Anti-FN1 / Fibronectin antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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FN1 / Fibronectin Mouse anti-Human Monoclonal (aa1965-2176) (2F4) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
FN1 / Fibronectin Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FN1 / Fibronectin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$594; 1 mg/$3,527
FN1 / Fibronectin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$585
FN1 / Fibronectin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
FN1 / Fibronectin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
FN1 / Fibronectin ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$719
FN1 / Fibronectin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
FN1 / Fibronectin Protein - Recombinant Fibronectin By SDS-PAGE
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E. coli
His, N-Terminal
14.8 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
FN1 / Fibronectin ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
FN1 / Fibronectin Antibody - Immunohistochemistry with rabbit anti fibronectin biotin conjugated at 20X with negative controls (right). Tissue: kidney. Fixation: FFPE buffered formalin 10% conc. Antigen retrieval: Heat, Citrate pH 6.2. Pressure Cooker (top) or EDTA pH 9.5 Pressure Cooker (bottom). Primary antibody: 2 ug/ml for 1 hour @ room T. Secondary antibody: Streptavidin. Conj. HRP 10 ug/ml circa 45 min. @ room T. Staining: antibody as precipitated red signal with a hematoxylin purple nuclear counterstain. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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FN1 / Fibronectin Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Bovine, Rat, Human, Monkey
ELISA, IHC, IP, WB
Biotin Conjugated
100 µg/$559
FN1 / Fibronectin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
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FN1 / Fibronectin Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Biotin Conjugated
100 µg/$878
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FN1 / Fibronectin Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$930
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FN1 / Fibronectin Mouse anti-Human Monoclonal (B476) Antibody
Human
IHC, IHC-Fr
Unconjugated
0.5 ml/$328
FN1 / Fibronectin Antibody - Immunohistochemistry-Paraffin: Fibronectin Antibody (2F4) - Immunohistochemical analysis of paraffin-embedded stomach cancer tissues using Fibronectin mouse mAb with DAB staining.
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FN1 / Fibronectin Mouse anti-Human Monoclonal (2F4) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
FN1 / Fibronectin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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FN1 / Fibronectin Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$460
FN1 / Fibronectin Antibody - IHC testing of FFPE pancreatic adenocarcinoma and Fibronectin antibody
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FN1 / Fibronectin Mouse anti-Human Monoclonal (HFN7.1) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
FN1 / Fibronectin Antibody - Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with Fibronectin antibody (568).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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FN1 / Fibronectin Mouse anti-Human Monoclonal (Azide-free, BSA-free) (568) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
FN1 / Fibronectin ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
FN1 / Fibronectin ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
0.27 - 200 ng/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$851
Viewing 1-25 of 268 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).