Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey (tested or 100% immunogen sequence identity)
IHC - Paraffin (3.75 µg/ml)
Western blot (0.01 - 0.03 µg/ml)
ELISA (1:8000) & (0.01 - 0.03 µg/ml)
Specificity and Use
FKBP4 / FKBP52 antibody was raised against synthetic peptide C-DHPTDTEMKEEQKSN from the C Terminus of human FKBP4 / FKBP52 (NP_002005.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset (87%).
Peptide ELISA: antibody detection limit dilution 1:8000. Western Blot: Approx 52kD band observed in Human Placenta lysates (calculated MW of 51.8kD according to NP_002005.1). Recommended concentration: 0.01-0.03 ug/ml.
FKBP4 / FKBP52 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506.