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Anti-Fibrinogen Antibody LS-C147773

Ordering

Wt. Vol. Conc. Price
- 1000 µl - $225
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular Fibrinogen Antibodies

Anti-Fibrinogen Antibody IHC-plus™ LS-B697
Goat Polyclonal to Human Fibrinogen
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-Fibrinogen Antibody (clone 27C8) LS-C52057
Mouse Monoclonal [clone 27C8] (IgG2a) to Human Fibrinogen
Human
Western blot, ELISA
Unconjugated
Anti-Fibrinogen Antibody LS-C150799
Rabbit Polyclonal (IgG) to Mouse Fibrinogen
Mouse, Rat
IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human Fibrinogen
Human
Immunodiffusion
Unconjugated

Details

Human Fibrinogen
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity absorbed
Unmodified

Applications

Immunodiffusion

Specificity and Use

Fibrinogen antibody was raised against human fibrinogen
Human Fibrinogen. The reactivity of the antiserum is restricted to fibrinogen. In immunoelectrophoresis and radial immunodiffusion (Ouchterlony), using various antiserum concentrations against fresh normal human plasma a single precipitin line is obtained which shows a reaction of identity with the precipitin line obtained with purified fibrinogen. No reaction is obtained with any other plasma protein component or serum. However, the antiserum may also react with fibrin monomers, circulating fibrinopeptides and fibrin degradation products. Cross-reactivity The antiserum does not cross react with any other component of human plasma. Inter-species cross- reactivity is a normal feature of antibodies to plasma proteins since they frequently share antigenic determinants. Cross-reactivity of this antiserum has not been tested in detail.
This product is intended for use in precipitating techniques as immunoelectrophoresis and single or double radial immunodiffusion to identify the presence of fibrinogen in human plasma or other body fluids or to determine its concentration. The normal concentration of fibrinogen in the blood is 2.5 to 3.5 ml /ml, but lower levels are usually adequate for haemostasis. In newborn infants the value is 1.2 to 2.4 mg/ml. Synthesis of fetal fibrinogen may persists for up to 8 weeks, when adult levels are reached. Adult level increase with age and are a risk for heart disease, myocardial infarction and stroke. Fibrinogen is an acute Phase protein and increased levels are found in loosing enteropathies, in severe malnutrition, in tissue necrosis and in malignancy. Extremely high levels are seen in acute pancreatitis and, to a lower extent, in nephritic syndrome. A moderate raise may also been seen during pregnancy and the use of oral contraceptives. Fibrinogen deficiency may be congenital or acquired. If sufficiently severe, it may result in a bleeding disorder. The congenital form is very rare. Acquired hypofibrinogaemia is relatively common, probably indicating increased consumption during intravascular clotting.

Packaging

Lyophilized antiserum
1,000 µl Sterile distilled water 1 ml
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About Fibrinogen

Fibrinogen (factor I) is a glycoprotein in vertebrates that helps in the formation of blood clots. It consists of a linear array of three nodules held together by a very thin thread which is estimated to have a diameter between 8 and 15 Angstrom (Å). The two end nodules are alike but the center one is slightly smaller. Measurements of shadow lengths indicate that nodule diameters are in the range 50 to 70 Angstrom. The length of the dried molecule is 475 ± 25 Angstrom.

Requested From: United States
Date Requested: 12/4/2016

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