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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Fibrinogen

Fibrinogen (factor I) is a glycoprotein in vertebrates that helps in the formation of blood clots. It consists of a linear array of three nodules held together by a very thin thread which is estimated to have a diameter between 8 and 15 Angstrom (Å). The two end nodules are alike but the center one is slightly smaller. Measurements of shadow lengths indicate that nodule diameters are in the range 50 to 70 Angstrom. The length of the dried molecule is 475 ± 25 Angstrom. The fibrinogen molecule is a soluble, large, and complex glycoprotein, 340 kDa plasma glycoprotein, that is converted by thrombin into fibrin during blood clot formation. It has a rod-like shape with dimensions of 9 × 47.5 × 6 nm and it shows a negative net charge at physiological pH (IP at pH 5.2). Fibrinogen is synthesized in the liver by the hepatocytes. The concentration of fibrinogen in the blood plasma is 200–400 mg/dL (normally measured using the Clauss method). During normal blood coagulation, a coagulation cascade activates the zymogen prothrombin by converting it into the serine protease thrombin. Thrombin then converts the soluble fibrinogen into insoluble fibrin strands. These strands are then cross-linked by factor XIII to form a blood clot. FXIIa stabilizes fibrin further by incorporation of the fibrinolysis inhibitors alpha-2-antiplasmin and TAFI (thrombin activatable fibrinolysis inhibitor, procarboxypeptidase B), and binding to several adhesive proteins of various cells. Both the activation of factor XIII by thrombin and plasminogen activator (t-PA) are catalyzed by fibrin. Fibrin specifically binds the activated coagulation factors factor Xa and thrombin and entraps them in the network of fibers, thus functioning as a temporary inhibitor of these enzymes, which stay active and can be released during fibrinolysis.

Fibrinogen Target Details

Target Name: Fibrinogen

Publications (1)

1
A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis. Cordova KN, Willis VC, Haskins K, Holers VM. Journal of immunology (Baltimore, Md. : 1950). 2013 190:1457-65. (WB; Mouse) [PubMed:23319740] Related Antibodies: LS-C129050.

Viewing 1-25 of 139 items
Fibrinogen Antibody - Anti-Fibrinogen antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Sheep Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, IF, IHC, IHC-Fr, IHC-P
Unconjugated
50µl   5mg/ml   $425.00
Fibrinogen Antibody - Anti-Fibrinogen antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Sheep Polyclonal (IgG) to Human Fibrinogen
Human
IF
FITC Conjugated
1ml   $365.00
Fibrinogen Antibody - Anti-Fibrinogen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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Goat Polyclonal to Human Fibrinogen
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   90mg/ml   $425.00
Fibrinogen Antibody - Anti-Fibrinogen antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Goat Polyclonal to Human Fibrinogen
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   10mg/ml   $425.00
Fibrinogen Antibody - Anti-Fibrinogen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, IHC, IHC-P, WB
Unconjugated
250µg   1mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human Fibrinogen
Human
ELISA
HRP Conjugated
1mg   $485.00; 10mg   $4,620.00
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Rabbit Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, WB
Biotin Conjugated
1mg   12.6mg/ml   $485.00
Fibrinogen Antibody - Anti-Fibrinogen antibody IHC of human small intestine, intravascular plasma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Mouse Monoclonal [clone 5C5] (IgG1,k) to Human Fibrinogen
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   4mg/ml   $425.00
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Rabbit Polyclonal (IgG) to Mouse Fibrinogen
Mouse, Rat
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
1mg   8.6mg/ml   $375.00; 10mg   $2,535.00
Select
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IF, IHC
Unconjugated
10mg   $295.00
Select
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IHC, WB
HRP Conjugated
1ml   $405.00
Select
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IHC
Biotin Conjugated
1ml   $325.00
Select
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IF
FITC Conjugated
1ml   $325.00
Select
Mouse Monoclonal [clone 27C8] (IgG2a) to Human Fibrinogen
Human
ELISA, WB
Unconjugated
0.2mg   $425.00; 0.5mg   6.3mg/ml   $545.00
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Rabbit Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, WB
Unconjugated
1ml   $405.00
Select
Rabbit Polyclonal to Mouse Fibrinogen
Mouse
ELISA, WB
Unconjugated
200µg   $365.00
Select
Rabbit Polyclonal (IgG) to Mouse Fibrinogen
Mouse
ELISA, WB
PE Conjugated
100µl   $1,065.00
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Mouse Monoclonal [clone MFB-HB] (IgM) to Human Fibrinogen
Human
ELISA, IF, IHC, IHC-Fr
Unconjugated, Concentrated
1ml   $345.00
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Goat Polyclonal to Mouse Fibrinogen
Mouse
ID
Unconjugated
1ml   $305.00
Select
Goat Polyclonal to Mouse Fibrinogen
Mouse
DB, ELISA, IF
Unconjugated
10mg   $435.00
Select
Rabbit Polyclonal to Human Fibrinogen
Rabbit, Human
Block, ELISA, IF
Unconjugated
250µl   $355.00
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Rabbit Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, WB
Unconjugated
0.1mg   $485.00
Select
Mouse Monoclonal [clone 1F3] (IgG1)
ELISA, WB
Unconjugated
1mg   $650.00
Select
Sheep Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, IE
Unconjugated
500µg   2mg/ml   $485.00
Select
Sheep Polyclonal (IgG)
Rabbit
ELISA, WB
Unconjugated
1mg   10mg/ml   $375.00; 10mg   $2,535.00

Viewing 1-25 of 139 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).