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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Fibrinogen

Fibrinogen (factor I) is a glycoprotein in vertebrates that helps in the formation of blood clots. It consists of a linear array of three nodules held together by a very thin thread which is estimated to have a diameter between 8 and 15 Angstrom (Å). The two end nodules are alike but the center one is slightly smaller. Measurements of shadow lengths indicate that nodule diameters are in the range 50 to 70 Angstrom. The length of the dried molecule is 475 ± 25 Angstrom. The fibrinogen molecule is a soluble, large, and complex glycoprotein, 340 kDa plasma glycoprotein, that is converted by thrombin into fibrin during blood clot formation. It has a rod-like shape with dimensions of 9 × 47.5 × 6 nm and it shows a negative net charge at physiological pH (IP at pH 5.2). Fibrinogen is synthesized in the liver by the hepatocytes. The concentration of fibrinogen in the blood plasma is 200–400 mg/dL (normally measured using the Clauss method). During normal blood coagulation, a coagulation cascade activates the zymogen prothrombin by converting it into the serine protease thrombin. Thrombin then converts the soluble fibrinogen into insoluble fibrin strands. These strands are then cross-linked by factor XIII to form a blood clot. FXIIa stabilizes fibrin further by incorporation of the fibrinolysis inhibitors alpha-2-antiplasmin and TAFI (thrombin activatable fibrinolysis inhibitor, procarboxypeptidase B), and binding to several adhesive proteins of various cells. Both the activation of factor XIII by thrombin and plasminogen activator (t-PA) are catalyzed by fibrin. Fibrin specifically binds the activated coagulation factors factor Xa and thrombin and entraps them in the network of fibers, thus functioning as a temporary inhibitor of these enzymes, which stay active and can be released during fibrinolysis.

Fibrinogen Target Details

Target Name: Fibrinogen

Publications (1)

1
A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis. Cordova KN, Willis VC, Haskins K, Holers VM. Journal of immunology (Baltimore, Md. : 1950). 2013 190:1457-65. (WB; Mouse) [PubMed:23319740] Related Antibodies: LS-C129050.

Filtered by: None
Target
Fibrinogen (138)
Reactivity
Human (67)
Mouse (30)
Rat (17)
Bovine (3)
Dog (10)
Pig (2)
Rabbit (16)
Application
IHC (27)
IHC-Fr (12)
IHC-P (16)
WB (57)
Flo (1)
Block (1)
DB (8)
ELISA (112)
GS (1)
ICC (8)
ID (18)
IE (18)
IF (14)
IP (1)
RIA (7)
Host
rabbit (36)
mouse (38)
goat (40)
chicken (1)
sheep (23)
Isotype
IgG (53)
IgG1 (26)
IgG1,k (3)
IgG2a (6)
IgG2a,k (1)
IgG2b (1)
IgM (1)
IgY (1)
Clonality
monoclonal mc (38)
polyclonal pc (100)
Clone
15E11 (1)
15H12 (1)
173602 (1)
1D6 (1)
1F3 (2)
20B2 (1)
23H2 (1)
27C8 (3)
3D1 (1)
3F2 (1)
40F11 (2)
41D9 (1)
5C5 (1)
6G12 (1)
MFB-HB (1)
Format
AP Conjugated (4)
APC Conjugated (3)
Biotin Conjugated (14)
Concentrated (5)
FITC Conjugated (17)
HRP Conjugated (18)
PE Conjugated (4)
Unconjugated (78)
Epitope
Citrullinated (2)
Publications
No (137)
Yes (1)
Showing 1-25 of 138 results

IHC-plus™ Fibrinogen Antibody LS-B2573
Sheep Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, IF, IHC, IHC-Fr, IHC-P
Unconjugated
50µl 5mg/ml  $425.00
Anti-Fibrinogen antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Fibrinogen Antibody (FITC) LS-C56206
Sheep Polyclonal (IgG) to Human Fibrinogen
Human
IF
FITC Conjugated
1ml  $365.00
Anti-Fibrinogen antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ Fibrinogen Antibody LS-B381
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl 90mg/ml  $425.00
Anti-Fibrinogen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.

IHC-plus™ Fibrinogen Antibody LS-B5249
Rabbit Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, IHC, IHC-P, WB
Unconjugated
250µg 1mg/ml  $425.00
Anti-Fibrinogen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Fibrinogen antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Fibrinogen Antibody (Biotin) LS-C109179
Rabbit Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, WB
Biotin Conjugated
1000µg 12.6mg/ml  $475.00

IHC-plus™ Fibrinogen Antibody LS-B697
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl 10mg/ml  $425.00
Anti-Fibrinogen antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Fibrinogen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Fibrinogen Antibody LS-C150799
Rabbit Polyclonal (IgG) to Mouse Fibrinogen
Mouse, Rat
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
1mg 8.6mg/ml  $365.00

Fibrinogen Antibody LS-C147228
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IF, IHC
Unconjugated
10mg  $285.00

Fibrinogen Antibody (HRP) LS-C147232
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IHC, WB
HRP Conjugated
1ml  $395.00

Fibrinogen Antibody (Biotin) LS-C147230
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IHC
Biotin Conjugated
1ml  $315.00

Fibrinogen Antibody (FITC) LS-C147231
Goat Polyclonal to Human Fibrinogen
Human
ELISA, IF
FITC Conjugated
1ml  $315.00

Fibrinogen Antibody (clone 27C8) LS-C52057
Mouse Monoclonal [clone 27C8] (IgG2a) to Human Fibrinogen
Human
ELISA, WB
Unconjugated
200µg  $425.00; 500µg 6.3mg/ml  $590.00

Fibrinogen Antibody LS-C109177
Rabbit Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, WB
Unconjugated
1ml  $395.00

Fibrinogen Antibody LS-C129050
Publications (1)
Publications (1)
Rabbit Polyclonal to Mouse Fibrinogen
Mouse
ELISA, WB
Unconjugated
200µg  $365.00

Fibrinogen Antibody (PE) LS-C654230
Rabbit Polyclonal (IgG) to Mouse Fibrinogen
Mouse
ELISA, WB
PE Conjugated
100µl  $1,065.00

IHC-plus™ Fibrinogen Antibody (clone 5C5) LS-B7075
Mouse Monoclonal [clone 5C5] (IgG1,k) to Human Fibrinogen
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl 4mg/ml  $425.00
Anti-Fibrinogen antibody IHC of human small intestine, intravascular plasma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Western blot Image

Fibrinogen Antibody (clone MFB-HB, Concentrated) LS-C134840
Mouse Monoclonal [clone MFB-HB] (IgM) to Human Fibrinogen
Human
ELISA, IF, IHC, IHC-Fr
Unconjugated, Concentrated
1ml  $345.00

Fibrinogen Antibody LS-C347317
Goat Polyclonal to Mouse Fibrinogen
Mouse
ID
Unconjugated
1ml  $305.00

Fibrinogen Antibody (FITC) LS-C346567
Goat Polyclonal to Mouse Fibrinogen
Mouse
ELISA, ICC, ID, IF, IHC, IHC-Fr
FITC Conjugated
1ml  $395.00

Fibrinogen Antibody LS-C346568
Goat Polyclonal to Mouse Fibrinogen
Mouse
DB, ELISA, IF
Unconjugated
10mg  $435.00

Fibrinogen Antibody LS-C96078
Rabbit Polyclonal to Human Fibrinogen
Rabbit, Human
Block, ELISA, IF
Unconjugated
250µl  $355.00

Fibrinogen Antibody LS-C109182
Rabbit Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, WB
Unconjugated
100µg 0.9mg/ml  $475.00

Fibrinogen Antibody (clone 1F3) LS-C85115
Mouse Monoclonal [clone 1F3] (IgG1)
ELISA, WB
Unconjugated
1mg  $650.00

Fibrinogen Antibody LS-C23582
Sheep Polyclonal (IgG) to Human Fibrinogen
Human
ELISA, IE
Unconjugated
500µg 2mg/ml  $455.00

Fibrinogen Antibody LS-C150983
Sheep Polyclonal (IgG)
Rabbit
ELISA, WB
Unconjugated
1mg 10mg/ml  $365.00
Showing 1-25 of 138 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).