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Catalog Number Size Price
LS-C188515-25 25 µg (1 mg/ml) $426 
LS-C188515-0.1 0.1 mg (1 mg/ml) $915 
Antibody

Monoclonal Mouse anti‑Human ESR2 / ER Beta Antibody (clone 5/25, aa493‑504, IHC, WB) LS‑C188515

Monoclonal Mouse anti‑Human ESR2 / ER Beta Antibody (clone 5/25, aa493‑504, IHC, WB) LS‑C188515

Note: This antibody replaces LS-C90445
Antibody:
ESR2 / ER Beta Mouse anti-Human Monoclonal (aa493-504) (5/25) Antibody
Application:
IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$426
LS-C188515-25
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
ESR2 / ER Beta Mouse anti-Human Monoclonal (aa493-504) (5/25) Antibody
Application:
IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
ER Beta antibody LS-C188515 is an unconjugated mouse monoclonal antibody to human ER Beta (ESR2) (aa493-504). Validated for IHC and WB.
Target
Human ESR2 / ER Beta
Synonyms
ESR2 | ESTRB | ER Beta | ERbeta | ER-BETA | ESR-BETA | ESRB | Estrogen receptor 2 (ER beta) | NR3A2 | Estrogen receptor beta | Estrogen receptor beta 4
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Clone
5/25
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Tuberculin conjugated synthetic peptide LLSHVRHARYAP derived from the C-Terminus of human ERB5. Percent identity by BLAST analysis: Human (100%); Ferret (92%).
Epitope
aa493-504
Specificity
Recognizes human estrogen receptor beta 5 (ERB5), a splice variant of the nuclear receptor hormone ERbeta (ESR2), shown to exist in at least five isoforms (ERB1-ERB5). Although only the ERB1 variant appears fully functional, the remaining isoforms have been shown to form heterodimers with ERB1, thereby enhancing transcription. Immunohistochemical studies have revealed a ubiquitous expression of ERB5 in normal colorectal tissue, and to be present in all primary colorectal carcinomas studied. Studies also revealed the nuclear expression of ERB5 in the majority of breast carcinomas tested, with a possible association with improved patient survival.
Applications
  • IHC - Paraffin
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ESR2 / ER Beta
Q92731 NM_001437 NP_001428.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/19/2024