Human ESR2 / ER Beta

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

5/25

Unconjugated

Protein G purified

Unmodified

Tuberculin conjugated synthetic peptide LLSHVRHARYAP derived from the C-Terminus of human ERB5. Percent identity by BLAST analysis: Human (100%); Ferret (92%).

aa493-504

Recognizes human estrogen receptor beta 5 (ERB5), a splice variant of the nuclear receptor hormone ERbeta (ESR2), shown to exist in at least five isoforms (ERB1-ERB5). Although only the ERB1 variant appears fully functional, the remaining isoforms have been shown to form heterodimers with ERB1, thereby enhancing transcription. Immunohistochemical studies have revealed a ubiquitous expression of ERB5 in normal colorectal tissue, and to be present in all primary colorectal carcinomas studied. Studies also revealed the nuclear expression of ERB5 in the majority of breast carcinomas tested, with a possible association with improved patient survival.

• IHC - Paraffin
• Western blot

PBS, 0.1% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q92731 NCBI: NM_001437 NP_001428.1