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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EIF2B5 Antibody (phospho‑Ser539) LS‑C23313
Antibody
EIF2B5 antibody LS-C23313 is an unconjugated rabbit polyclonal antibody to EIF2B5 from human and rat. Validated for Func and WB.
Catalog
Size
Price
LS-C23313-10
10 blot
Unavailable

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Antibody
Species: Human, Mouse
Applications: IHC, Western blot, ELISA

Product Description

EIF2B5 antibody LS-C23313 is an unconjugated rabbit polyclonal antibody to EIF2B5 from human and rat. Validated for Func and WB.
About EIF2B5
EIF2B5 is one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. Q13144 U23028 AAC50646.1

EIF2B5 Antibody, CACH Antibody, EIF2BE Antibody, EIF-2B Antibody, LVWM Antibody, CLE Antibody, EIF2Bepsilon Antibody


Specifications

Target
Human EIF2B5
Host
Rabbit
Reactivity
Human, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot
  • Functional Assay
Immunogen
EIF2B5 antibody was raised against synthetic phosphopeptide derived from the region of rat eIF2B that contains serine 535 (corresponding to serine 539 in the human sequence).
Epitope
pSer539
Specificity
Human (80% homologous) and rat eIF2B.
Usage
The antibody has been used in Western blotting. Eukaryotic Initiation Factor 2B (eIF2B) plays a key role in the initiation of mRNA translation in eukaryotic cells by acting as a guanine nucleotide exchange factor. The activity of eIF2B is regulated by a wide array of conditions. Stress inhibits its action, while stimulation of protein synthesis results in its activation. eIF2B, an 82kD subunit of eIF2B, is phosphorylated at serine 539 by glycogen synthase kinase-3 (GSK-3), which leads to inhibition of its guanine nucleotide exchange activity. Positive control: Recombinant eIF2B treated with GSK-3 ; CHO-T cells transfected with human insulin receptor (IR) +/- insulin.
Presentation
PBS (without Mg2+, Ca2+), 1 mg/ml BSA (IgG, protease free), pH 7.2, 0.1% sodium azide, 50% glycerol.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/22/2018

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