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Anti-EIF2B5 Antibody (phospho-Ser539) LS-C23313

Catalog Size Price
LS-C23313-10 10 blot Unavailable

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100% Guaranteed
Rabbit Polyclonal to Human EIF2B5
Human, Rat
Western blot, Functional Assay


Human EIF2B5
Human, Rat (tested or 100% immunogen sequence identity)
Immunoaffinity purified


  • Western blot
  • Functional Assay

Specificity and Use

EIF2B5 antibody was raised against synthetic phosphopeptide derived from the region of rat eIF2B that contains serine 535 (corresponding to serine 539 in the human sequence).
Human (80% homologous) and rat eIF2B.
The antibody has been used in Western blotting. Eukaryotic Initiation Factor 2B (eIF2B) plays a key role in the initiation of mRNA translation in eukaryotic cells by acting as a guanine nucleotide exchange factor. The activity of eIF2B is regulated by a wide array of conditions. Stress inhibits its action, while stimulation of protein synthesis results in its activation. eIF2B, an 82kD subunit of eIF2B, is phosphorylated at serine 539 by glycogen synthase kinase-3 (GSK-3), which leads to inhibition of its guanine nucleotide exchange activity. Positive control: Recombinant eIF2B treated with GSK-3 ; CHO-T cells transfected with human insulin receptor (IR) +/- insulin.


PBS (without Mg2+, Ca2+), 1 mg/ml BSA (IgG, protease free), pH 7.2, 0.1% sodium azide, 50% glycerol.
For research use only.

About EIF2B5

Q13144 U23028 AAC50646.1

EIF2B5 Antibody, CACH Antibody, EIF2BE Antibody, EIF-2B Antibody, LVWM Antibody, CLE Antibody, EIF2Bepsilon Antibody

EIF2B5 is one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.

Requested From: 
Date Requested: 4/21/2018

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