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Anti-EGLN1 / PHD2 Antibody (aa1-24, clone 366G/76/3, HRP) LS-C188436


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $305
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular EGLN1 / PHD2 Antibodies

Anti-EGLN1 / PHD2 Antibody (aa159-176) LS-C3375
Rabbit Polyclonal to Human EGLN1 / PHD2
Anti-EGLN1 / PHD2 Antibody (C-Terminus) LS-C90115
Rabbit Polyclonal to Human EGLN1 / PHD2
Western blot
Anti-EGLN1 / PHD2 Antibody (aa1-50) IHC-plus™ LS-B4810
Rabbit Polyclonal to Human EGLN1 / PHD2
Human, Primate
IHC - Paraffin, Western blot
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 366G/76/3] (IgG1) to Human EGLN1 / PHD2
IHC - Paraffin, Western blot
HRP Conjugated


Human EGLN1 / PHD2
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [366G/76/3]
Horseradish Peroxidase
Protein G purified


  • IHC - Paraffin
  • Western blot

Specificity and Use

EGLN1 / PHD2 antibody was raised against pHD2 amino acids 1-24.
Recognizes human prolyl hydroxylase 2 (PHD2), a 46kD enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.
The applications listed have been tested for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.


PBS, 0.01% Thimerosal
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About EGLN1 / PHD2

Q9GZT9 NM_022051 NP_071334.1

EGLN1 Antibody, C1orf12 Antibody, EGL9 Antibody, ECYT3 Antibody, Egl nine-like protein 1 Antibody, HIFPH2 Antibody, HIF prolyl hydroxylase 2 Antibody, HIF-PH2 Antibody, HIF-prolyl hydroxylase 2 Antibody, ZMYND6 Antibody, PHD2 Antibody, SM20 Antibody, EGL nine (C.elegans) homolog 1 Antibody, Egl nine homolog 1 Antibody, HPH-2 Antibody, HPH2 Antibody, SM-20 Antibody

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B.

Requested From: United States
Date Requested: 10/23/2016

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