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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CYCS / Cytochrome c Antibody (clone 2G8) LS‑C58283
Antibody
Cytochrome c antibody LS-C58283 is an unconjugated mouse monoclonal antibody to Cytochrome c (CYCS) from human, mouse, rat and other species. Validated for ELISA, Flow and WB.
Catalog
Size
Price
LS-C58283-100
100 µg
Unavailable

Popular CYCS / Cytochrome c Products

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Product Description

Cytochrome c antibody LS-C58283 is an unconjugated mouse monoclonal antibody to Cytochrome c (CYCS) from human, mouse, rat and other species. Validated for ELISA, Flow and WB.
About CYCS / Cytochrome c
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. P99999 NM_018947 NP_061820.1

CYCS Antibody, CYC Antibody, HCS Antibody, THC4 Antibody, Cytochrome c Antibody, Cytochrome c, somatic Antibody


Specifications

Target
Human CYCS / Cytochrome c
Host
Mouse
Reactivity
Human, Mouse, Rat, Rabbit (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [2G8]
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • Western blot
  • Flow Cytometry
  • ELISA
Immunogen
Human cytochrome c.
Specificity
Recognizes cytochrome c, originally termed Apaf-2, an evolutionarily conserved protein which acts as an essential mitochondrial electron carrier between respirable substrates and oxygen, during aerobic energy production. A second major function for cytochrome c is its role as an intermediate in apoptosis, both through its association with inositol-3-phosphate receptor (IP3 receptor) which acts as an ER calcium release channel, and its association with apoptotic protease activating factor 1 (Apaf-1), resulting in the formation of the apoptosome protein complex which then recruits and activates pro-caspase 9 (Apaf-3). Clone 2G8 is reported to block the role of cytochrome c as a co-factor in the activation of caspase 9. Removal of sodium azide is recommended prior to use in functional assays.
Usage
Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request.
Presentation
0.09% sodium azide.
Storage
Short term: -20°C; Long term: -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/21/2018

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