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Anti-CTSK / Cathepsin K Antibody IHC-plus™ LS-B2512

Note: This antibody replaces LS-C48544
Catalog Size Price
LS-B2512-50 50 µg (0.5 mg/ml) Unavailable

Most Popular CTSK / Cathepsin K Antibodies

Anti-CTSK / Cathepsin K Antibody LS-C75060
Rabbit Polyclonal (IgG) to Human CTSK / Cathepsin K
Human
Western blot, ELISA
Unconjugated
Anti-CTSK / Cathepsin K Antibody IHC-plus™ LS-B2512
Rabbit Polyclonal to Rat CTSK / Cathepsin K
Rat, Human, Mouse, Pig, Rabbit, Chicken
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image
Anti-CTSK / Cathepsin K Antibody IHC-plus™ LS-B2531
Rabbit Polyclonal to Rat CTSK / Cathepsin K
Rat, Human, Mouse
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image
Anti-CTSK / Cathepsin K Antibody (clone 2F1) IHC-plus™ LS-B4308
Mouse Monoclonal [clone 2F1] (IgG2a,k) to Human CTSK / Cathepsin K
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-CTSK / Cathepsin K Antibody LS-C122819
Mouse Monoclonal (IgG2b) to Human CTSK / Cathepsin K
Human
IHC, Western blot, ELISA
Unconjugated

100% Guaranteed
Rabbit Polyclonal to Rat CTSK / Cathepsin K
Rat, Human, Mouse, Pig, Rabbit, Chicken
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated

Details

Rat CTSK / Cathepsin K
Rabbit
Rat, Human, Mouse, Pig, Rabbit, Chicken (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Protein A purified
Unmodified

Applications

  • IHC - Paraffin (2.5 µg/ml)
  • Western blot (0.5 - 4 µg/ml)
  • Immunoprecipitation

Specificity and Use

Synthetic peptide surrounding amino acid 321 of rat cathepsin K.
The antibody detects proform (43 kD) and the mature form (29 kD) of cathepsin K.
Immunohistochemistry: LS-B2512 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2512 was determined to be 2.5 ug/ml.

Packaging

PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.01% Thimerosal.
Short term: -20°C; Long term: -70°C.
For research use only.

About CTSK / Cathepsin K

P43235 NM_000396 NP_000387.1

CTSK Antibody, Cathepsin K Antibody, Cathepsin K (pycnodysostosis) Antibody, Cathepsin O1 Antibody, Cathepsin O2 Antibody, Cathepsin X Antibody, CTSO2 Antibody, PKND Antibody, Procathepsin K Antibody, PYCD Antibody, Cathepsin O Antibody, CTS02 Antibody, CTSO1 Antibody

CTSK / Cathepsin K is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Immunohistochemistry

Immunohistochemistry
Anti-CTSK / Cathepsin K antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2512 concentration 5 ug/ml.

Western blot

Western blot
Western blot of Cathepsin K antibody LS-B2512 with rat kidney lysates.

Requested From: 
Date Requested: 12/13/2017

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