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CRH / CRF

corticotropin releasing hormone

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.

Gene Name: corticotropin releasing hormone
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: CRH, CRF, Corticoliberin
Target Sequences: NM_000756 NP_000747.1 P06850

Publications (2)

1
Expression of Stress-Mediating Genes is Increased in Term Placentas of Women with Chronic Self-Perceived Anxiety and Depression. Cristina A Martinez, Ina Marteinsdottir, Ann Josefsson, Gunilla Sydsjö, Elvar Theodorsson, Heriberto Rodriguez-Martinez. Genes. 2020 July;11: [Full Text Article] [PubMed:32752005] [PMC:PMC7463995] Related Antibodies: LS-B11889.
2
Circulating levels of urocortin neuropeptides are impaired in children with overweight. Sina Kavalakatt, Abdelkrim Khadir, Dhanya Madhu, Sriraman Devarajan, Samia Warsame, Hessa AlKandari, Maria AlMahdi, Heikki A Koistinen, Fahd Al-Mulla, Jaakko Tuomilehto, Jehad Abubaker, Ali Tiss. Obesity (Silver Spring, Md.). 2022 Feburary;30:472-481. [Full Text Article] [PubMed:35088550] [PMC:PMC9305428]

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Antibodies (107)
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CRH / CRF Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRH / CRF Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CRH / CRF Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRH / CRF Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
CRH / CRF Antibody - Anti-CRH antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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CRH / CRF Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
250 µl/$505
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CRH / CRF Mouse anti-Human Monoclonal Antibody
Mouse, Dog, Rat, Pig, Human
ICC, IP, WB
Unconjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$577; 2 ml/$789; 5 ml/$1,281
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CRH / CRF Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Dog, Rat, Pig, Human
ICC, IP, WB
Biotin Conjugated
100 µl/$323; 200 µl/$372; 500 µl/$533; 1 ml/$620; 2 ml/$853; 5 ml/$1,411
CRH / CRF Antibody - Western Blot analysis of CRH expression in transfected 293T cell line by CRH monoclonal antibody (M02), clone 2B11.Lane 1: CRH transfected lysate(21.4 KDa).Lane 2: Non-transfected lysate.
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CRH / CRF Mouse anti-Human Monoclonal (2B11) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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CRH / CRF Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Cat, Human
ELISA
Unconjugated
400 µg/$878
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$764
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
CRH / CRF ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
12.35 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
CRH / CRF ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
2.19 - 140 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
CRH / CRF ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CRH / CRF ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
3.91 - 250 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
CRH / CRF ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CRH / CRF ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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CRH / CRF Rabbit anti-Human Polyclonal Antibody
Human
IP, RIA
Unconjugated
100 µl/$600
CRH / CRF ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CRH / CRF ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
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CRH / CRF Mouse anti-Human Monoclonal (5D5) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
0.2 mg/$486
CRH / CRF Antibody - Immunohistochemistry of CRH in human brain tissue with CRH antibody at 5 ug/mL.
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CRH / CRF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
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CRH / CRF Rabbit anti-Sheep Polyclonal Antibody
Sheep
ICC, IHC
Unconjugated
50 µl/$572
CRH / CRF Antibody - Western blot of recombinant CRH / CRF.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRH / CRF Rabbit anti-Mouse Polyclonal (aa28-160) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
CRH / CRF Antibody - E coli-derived fusion protein as test antigen. CRH / CRF Antibody dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
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CRH / CRF Chicken anti-Human Polyclonal (aa27-196) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$818
CRH / CRF Antibody - Western blot of recombinant CRH / CRF.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CRH / CRF Rabbit anti-Rat Polyclonal (aa39-187) Antibody
Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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CRH / CRF Mouse anti-Human Monoclonal (4H9) Antibody
Human
ELISA, IF, IHC-Fr, IHC-P
Unconjugated
0.2 mg/$486
Viewing 1-25 of 144 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).