Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone CC1] (IgG1) to Human CMA1 / Mast Cell Chymase
IHC, Western blot
Human CMA1 / Mast Cell Chymase
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [CC1]
Specificity and Use
CMA1 / Mast Cell Chymase antibody was raised against bALB/C mice were injected with a purified human skin Chymase.
Reacts with mast cells distributed in skin, synovium, lung and heart. Mast cells contain a number of preformed chemicals mediators such as histamine, Chymase, carboxypeptidase and proteolytic Tryptase. Human mast cell chymase is considered to be an important marker of mast cells as well as an important mediator of inflammation.
CMA1 / MCT1 / Chymase is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II.