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CMA1 / Mast Cell Chymase

chymase 1, mast cell

CMA1 / MCT1 / Chymase is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants.

Gene Name: chymase 1, mast cell
Family/Subfamily: Protease , Serine S1
Synonyms: CMA1, Chymase, Chymase, heart, Chymase, mast cell, CYH, Mast cell chymase, Mcpt5, MCT1, Mast cell protease 5, Mast cell protease I, Heart chymase, Alpha-chymase, Chymase 1, Chymase 1, mast cell, CYM
Target Sequences: NM_001836 NP_001827.1 P23946

Publications (1)

1
The muscular expression of RAS in patients with achalasia. Casselbrant A, Kostic S, Lönroth H. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2014 16:578-86. (WB; Human) [Full Text Article] [PubMed:24468662]

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).