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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CHRM2 / M2 Antibody (aa225‑359) LS‑C9134
M2 antibody LS-C9134 is an unconjugated rat monoclonal antibody to M2 (CHRM2) from human, rat and monkey. Validated for ICC, IHC and WB.
Antibody
Catalog
Size
Price
LS-C9134-100
100 µg
$635

Popular CHRM2 / M2 Products

Anti-CHRM2 / M2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Pig, Rabbit, Sheep
Applications: IHC, IHC - Paraffin
Antibody
Species: Human, Mouse, Rat, Guinea pig, Pig
Applications: IHC, IHC - Frozen, Immunofluorescence, Western blot, Functional Assay
Anti-CHRM2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A1831 dilution 10 ug/ml.
Species: Human, Monkey, Bovine, Rabbit, Sheep
Applications: IHC, IHC - Paraffin
Antibody
Species: Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Horse, Pig, Sheep
Applications: IHC, IHC - Frozen, Immunofluorescence, Western blot, ELISA
Anti-CHRM2 antibody LS-A1333 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Species: Human, Monkey, Mouse, Rat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Sheep
Applications: IHC, IHC - Paraffin

Product Description

M2 antibody LS-C9134 is an unconjugated rat monoclonal antibody to M2 (CHRM2) from human, rat and monkey. Validated for ICC, IHC and WB.

Specifications

Target
Human CHRM2 / M2
Synonyms
CHRM2, 7TM receptor, HM2, M2 muscarinic receptor, M2-mAChR, Muscarinic receptor M2, Muscarinic M2 receptor
Host
Rat
Reactivity
Human, Monkey, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • ICC
  • Western blot
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CHRM2 / M2 antibody was raised against i3 loop of m2 receptor fusion protein (225-359), fused to Glutathione S-transferase.
Epitope
aa225-359
Specificity
M2 muscarinic acetylcholine receptor. No reactivity with the other subtypes. Species cross-reactivity: Human, monkey and rat. Expected to react with most mammalian species.
Usage
Suitable for use in Immunohistochemistry and Immunocytochemistry. Does not work on paraffin embedded tissues, and Western Blot. Immunohistochemistry (4% paraformaldehyde fixed tissue): 1-5 ug/ml.
Presentation
PBS, pH 7.2, 0.1% Sodium Azide
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
About CHRM2 / M2
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. P08172 NM_000739 NP_000730.1


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Requested From: United States
Date Requested: 10/22/2018

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