Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin
IHC - Frozen
Flow Cytometry (1 - 2 µg/ml)
Specificity and Use
CD95 / FAS antibody was raised against human Fas (CD95; APO-1).
Recognizes human Fas.
Immunohistochemistry (frozen sections): This product is an isotype-switch variant of the original clone. Since undesired side reactions in immunohistochemistry are minimal for IgG1 antibodies, this clone is especially useful for immunohistology on cryostat sections and on cytospin preparations . Note: Not suitable for stainings on paraffin sections. Flow Cytometry: 1-2 ug/ml. Functional Application: Induces apoptosis upon cross-linking .
CD95 / FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10.