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Anti-CD59 Antibody (clone MEM-43/5) IHC-plus™ LS-B1853

Note: This antibody replaces LS-C45838
Catalog Size Price
LS-B1853-50 50 µg (1 mg/ml) Unavailable

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100% Guaranteed
Mouse Monoclonal [clone MEM-43/5] (IgG2b) to Human CD59
Human, Mouse
IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Unconjugated

Details

Human CD59
Mouse
Human, Mouse (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [MEM-43/5]
Unconjugated
Protein A purified
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • Western blot (1 - 2 µg/ml)
  • Immunoprecipitation
  • Flow Cytometry (1 µg/ml)

Specificity and Use

CD59 antibody was raised against cells.
Thymocytes and T lymphocytes
Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody,

Packaging

PBS, 15 mM sodium azide, approx., pH 7.4.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About CD59

P13987 NM_000611 NP_000602.1

CD59 Antibody, 16.3A5 Antibody, 1F5 Antibody, 1F5 antigen Antibody, CD59 glycoprotein Antibody, EL32 Antibody, EJ16 Antibody, G344 Antibody, HRF-20 Antibody, MAC-IP Antibody, MACIF Antibody, Ly-6-like protein Antibody, MEM43 Antibody, MIRL Antibody, MEM43 antigen Antibody, MIN2 Antibody, MIN3 Antibody, MSK21 Antibody, p18-20 Antibody, Protectin Antibody, MAC-inhibitory protein Antibody, MIC11 Antibody, T cell-activating protein Antibody, CD59 antigen Antibody, EJ30 Antibody, HRF20 Antibody, Human leukocyte antigen MIC11 Antibody, Lymphocytic antigen CD59/MEM43 Antibody, MIN1 Antibody

CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation.

Immunohistochemistry

Immunohistochemistry
Anti-CD59 antibody IHC of human skin, pilosebaceous unit. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1853 concentration 5 ug/ml.

Requested From: 
Date Requested: 12/12/2017

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