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Catalog Number Size Price
LS-B1852-0.05 0.05 mg (1 mg/ml) $440 
CD59 Antibody - Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

PathPlus™ Monoclonal Mouse anti‑Human CD59 Antibody (clone MEM‑43, IHC) LS‑B1852

PathPlus™ Monoclonal Mouse anti‑Human CD59 Antibody (clone MEM‑43, IHC) LS‑B1852

Note: This antibody replaces LS-C45836
Antibody:
CD59 Mouse anti-Human Monoclonal (MEM-43) Antibody
Application:
IHC, IHC-P, IP, Flo, Func
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$440
LS-B1852-0.05
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
CD59 Mouse anti-Human Monoclonal (MEM-43) Antibody
Application:
IHC, IHC-P, IP, Flo, Func
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CD59 (MAP-IP, MIRL, protectin) is a cell surface glycoprotein that regulates complement-mediated cell lysis and is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, and it binds complement C8 and/or C9 during the assembly of this complex. This inhibits the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia, thrombosis, and cerebral infarction. In cancer, CD59 is positive in squamous cell carcinoma of the head and neck and in ovarian cancer, and sees upregulation in non-small cell lung cancer (NSCLC) and late stage colorectal cancer. In immunohistochemistry of normal tissues, CD59 has membranous and cytoplasmic positivity in tissues throughout the body. References: Journal of autoimmunity. 2014 53:67-77, PubMed:24698947; J Oral Pathol Med 2006;35:560, PMID: 16968237; Cent Eur J Immunol. 2015; 40(3): 349–353, PMID: 26648780; Arch Pathol Lab Med. 2014 Jul;138(7):910-9, PMID: 24978917; International Journal of Oncology. 2013. 43.3: 850-858, DOI: 10.3892/ijo.2013.2007
Target
Human CD59
Synonyms
CD59 | 16.3A5 | 1F5 | 1F5 antigen | CD59 glycoprotein | EL32 | EJ16 | G344 | HRF-20 | MAC-IP | MACIF | Ly-6-like protein | MEM43 | MIRL | MEM43 antigen | MIN2 | MIN3 | MSK21 | p18-20 | Protectin | MAC-inhibitory protein | MIC11 | T cell-activating protein | CD59 antigen | EJ30 | HRF20 | Human leukocyte antigen MIC11 | Lymphocytic antigen CD59/MEM43 | MIN1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Clone
MEM-43
Conjugations
Unconjugated. Also available conjugated with Biotin.
Purification
Purified by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
Modifications
Unmodified
Immunogen
Thymocytes and T lymphocytes.
Specificity
The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues.
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • Immunoprecipitation
  • Flow Cytometry
  • Functional Assay
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 15mM sodium azide
Storage
Store at 2°C to 8°C. Do not freeze.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD59
P13987 NM_000611 NP_000602.1

Validation

CD59 Antibody - Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

LSBio Ratings

PathPlus™ CD59 Antibody (clone MEM-43) for IHC, IP, Flow LS-B1852 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia. Christopher J Peters, Jonathan R E Rees, Richard H Hardwick, James S Hardwick, Sarah L Vowler, Chin-Ann J Ong, Chunsheng Zhang, Vicki Save, Maria O'Donovan, Doris Rassl, Derek Alderson, Carlos Caldas, Rebecca C Fitzgerald, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group. Gastroenterology. 2010 December;139:1995-2004.e15.

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 5/25/2022