Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone DF 1485] (IgG1) to Human CD44
IHC - Paraffin, IHC - Frozen
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [DF 1485]
IHC - Paraffin
IHC - Frozen
Specificity and Use
CD44 antibody was raised against isolated CD44 antigen.
HCAM, CD44 is a transmembrane glycoprotein which is expressed by lymphocytes and several normal epithelial cells. The CD44 molecule is involved in lymphocyte homing, T-lymphocyte actvitation, interaction with hyaluronic acid and may act as an adhesion molecule. Standard CD 44 (CD44s) is composed of the products of exons 1-5 a less favorable prognosis in gastrointestinal cancers, the loss of CD44s expression predicts unfavorable outcome in bladder cancers, squamous cell carcinomas of the skin, prostatic adenocarcinomas and neuroblastomas. In immunoblotting this antibody reacts with a glycoprotein isolated from hemopoietic cells and epithelials cells with a respective molecular weight of 29-37 and 51 kD.
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis.