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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

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CD274 / B7‑H1 / PD‑L1 Antibody (Internal) LS‑C19686
PD-L1 antibody LS-C19686 is an unconjugated rabbit polyclonal antibody to human PD-L1 (CD274 / B7-H1). Validated for IHC and WB.
Catalog
Size
Price
LS-C19686-100
100 µg (1 mg/ml)
$365

Popular CD274 / B7-H1 / PD-L1 Products

Flow Cytometry Image
Species: Human
Applications: IHC, IHC - Paraffin, Flow Cytometry
Flow cytometry of B7-H1 / PD-L1 / CD274 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: Flow Cytometry, ELISA
Flow cytometry of B7-H1 / PD-L1 / CD274 antibody This image was taken for the unmodified form of this product. Other forms have not been tested.
Species: Human
Applications: Flow Cytometry, ELISA
Flow cytometry of B7-H1 / PD-L1 / CD274 antibody
Species: Human
Applications: Flow Cytometry, ELISA
Anti-B7-H1 / PD-L1 / CD274 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10562 dilution 1:100.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot

Product Description

PD-L1 antibody LS-C19686 is an unconjugated rabbit polyclonal antibody to human PD-L1 (CD274 / B7-H1). Validated for IHC and WB.
About CD274 / B7-H1 / PD-L1
CD274, also known as B7-H1 and PD-L1, a cell surface glycoprotein, is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T-cells, B-cells, endothelial cells and epithelial cells in response to interferons. CD274 has dual functions: inhibition of activated effector T cells and co-stimulation of naïve T cells. Q9NZQ7 NM_014143 NP_054862.1

CD274 Antibody, B7-H Antibody, B7 homolog 1 Antibody, B7-H1 Antibody, B7H1 Antibody, CD274 molecule Antibody, CD274 antigen Antibody, PDCD1 ligand 1 Antibody, PDL1 Antibody, PD-L1 Antibody, PDCD1L1 Antibody, PDCD1LG1 Antibody, Programmed death ligand 1 Antibody


Specifications

Target
Human CD274 / B7-H1 / PD-L1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC (5 µg/ml)
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Blocking Peptide
LS-E30319 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-C19686. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Internal
Specificity
PD-L1 antibody has no cross-reactivity to PD-L2.
Presentation
PBS, 0.02% Sodium Azide
Storage
Store at 4°C for 3 months and -20°C, stable for up to 1 year. Avoid repeated freeze-thaw cycles.
Restrictions
For research use only.

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Images

Western blot

Western blot of PDL-1 in Raji cell lysate with PDL-1 antibody at (A) 0.5 and (B) 1 ug/ml.
Western blot of PDL-1 in Raji cell lysate with PDL-1 antibody at (A) 0.5 and (B) 1 ug/ml.

Western blot

Western blot of PDL-1 in Raji cell lysate with PDL-1 antibody at (A) 0.5 and (B) 1 ug/ml.
Western blot of PDL-1 in Raji cell lysate with PDL-1 antibody at (A) 0.5 and (B) 1 ug/ml.

Western blot

Western blot of PDL-1 in Raji cell lysate with PDL-1 antibody at (A) 0.5 and (B) 1 ug/ml.
Western blot of PDL-1 in Raji cell lysate with PDL-1 antibody at (A) 0.5 and (B) 1 ug/ml.

Western blot

Western blot of PDL-1 in Raji cell lysate with PDL-1 antibody at (A) 0.5 and (B) 1 ug/ml.
Western blot of PDL-1 in Raji cell lysate with PDL-1 antibody at (A) 0.5 and (B) 1 ug/ml.

Requested From: United States
Date Requested: 9/22/2018

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