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Anti-CD22 Antibody LS-C152867


Wt. Vol. Conc. Price
100 µg - - $305
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular CD22 Antibodies

Anti-CD22 Antibody LS-C4802
Mouse Monoclonal (IgG1) to Human CD22
IHC - Paraffin
Anti-CD22 Antibody (clone 4C3) LS-C174778
Mouse Monoclonal [clone 4C3] (IgG1) to Human CD22
Human, Monkey, Mouse, Rat, Dog
IHC - Paraffin, Western blot
Immunohistochemistry Image
Anti-CD22 Antibody (C-Terminus, clone SP104) LS-C210357
Rabbit Monoclonal [clone SP104] (IgG) to Human CD22
IHC - Paraffin, Flow Cytometry
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG1) to Human CD22
IHC - Frozen, Immunofluorescence, Immunoprecipitation, Flow Cytometry


Human CD22
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal


  • IHC - Frozen
  • Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry

Specificity and Use

CD22 antibody was raised against human tonsil lymphocytes
The CD22 antigen is a heterodimer composed of two glycoprotein chains of 130-140 kD and is present as both a cytoplasmic and membrane antigen on B lymphocytes. Antigen expression appears at an early stage in B lymphocyte differentiation at approximately the same stage as the CD19 antigen. Surface expression of the CD22 antigen by B lymphocytes is variable. Circulating B lymphocytes are CD22 positive and follicular mantle and marginal zone B lymphocytes show strong binding of this antibody. Germinal centre B cells exhibit only weak expression of the CD22 antigen. The CD22 antigen is poorly expressed by non T ALL cells and by a proportion of B CLL cells. Hairy cell leukaemia cells have been demonstrated to strongly express the CD22 antigen. CD22 functions as a sialic acid binding lectin specifically sialic acid in alpha-2,6 linkage. Sialylation of CD22 by alpha-2,6 sialyl transferase inhibits CD22 ligand binding. Antigen distribution: B cells (lg+, E-) 92+/- 3%; Peripheral blood lymphocytes 12 +/- 3%; Thymocytes < 1%; Granulocytes < 1%; Monocytes >1%T cells (E+) >1%
Identification of B lymphocytes and HCL cells by indirect immunofluorescence staining. Identification of B lymphocytes and B lymphocyte progenitor cells by staining of cytoplasmic CD22 antigen using the APAAP technique. Staining of B lymphocytes in frozen


PBS, 10 mM sodium azide, 1 mg/ml BSA
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About CD22

P20273 NM_001771 NP_001762.2

CD22 Antibody, CD22 molecule Antibody, CD22 antigen Antibody, SIGLEC2 Antibody, SIGLEC-2 Antibody, T-cell surface antigen Leu-14 Antibody, B-cell receptor CD22 Antibody, BL-CAM Antibody

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling.


IHC: Staining of B lymphocytes in the mantle zone on frozen sections of human tonsil using LS-C152867.

Requested From: United States
Date Requested: 10/21/2016

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