Target
Human CD163
Synonyms
CD163 | CD163 antigen | Macrophage-associated antigen | M130 | CD163 molecule | Hemoglobin scavenger receptor | MM130
Reactivity
Human
(tested or 100% immunogen sequence identity)
Specificity
The antigen is CD163, the epitope has not been further characterized. Antigen distribution: Isolated cells: Monocytes, particularly after dexamethasone treatment or after 2-5 days in culture. Does not react with lymphocytes, granulocytes or platelets. Tissue sections: Positive staining can be observed in the skin (histiocytes), gut, Kupffer cells, few alveolar macrophages, a major population of macrophages in the placenta, varying degrees of macrophages in inflamed tissues, including tumorous tissue depending on the inflammatory stage. Red pulp, but not white pulp macrophages of the spleen, and cortical macrophages of the thymus are detected. Macrophages in the synovialis of patients with rheumatoid arthritis. In alveolar macrophages and in Kupffer cells a double staining can be observed with monoclonal antibody 25F9 which is not the case in other tissues. Specificity: Human: monocytes and macrophages. Other: not tested.