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The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.
Gene Name: | BCL2-associated athanogene |
Synonyms: | BAG1, Bcl-2-associated athanogene 1, Bcl-2-binding protein, Bcl2 binding protein bag1, BCL2-associated athanogene, BAG-1, Bcl2 binding athanogene1, HAP, RAP46 |
Target Sequences: | NM_004323 |
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