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Anti-AR / Androgen Receptor Antibody (aa1242-1255) LS-C41662

Ordering

Wt. Vol. Conc. Price
- 1000 µl 2.1 mg/ml $375
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular AR / Androgen Receptor Antibodies

Anti-AR / Androgen Receptor Antibody (clone AR 441) LS-C87494
Mouse Monoclonal [clone AR 441] (IgG1) to Human AR / Androgen Receptor
Human, Dog
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, Gel shift
Unconjugated
Immunohistochemistry Image
Anti-AR / Androgen Receptor Antibody (N-Terminus) IHC-plus™ LS-B3326
Rabbit Polyclonal to Human AR / Androgen Receptor
Human, Mouse, Rat
IHC - Paraffin
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human AR / Androgen Receptor
Human
IHC - Paraffin
Unconjugated

Details

Human AR / Androgen Receptor
Rabbit
Human (tested or 100% immunogen sequence identity)
Rhesus monkey (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Ammonium sulfate precipitation
Unmodified

Applications

IHC - Paraffin (1:25 - 1:100)

Specificity and Use

AR / Androgen Receptor antibody was raised against synthetic peptide corresponding to the amino acids 1242 - 1255 of the native molecule conjugated to Keyhole limpet Hemocyanin.
aa1242-1255
Recognizes the human Androgen Receptor (AR) also known as the Dihydrotestosterone receptor or Nuclear receptor subfamily 3 group C member 4. Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions. AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, survival, and proliferation. Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development. AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity.

Packaging

PBS, pH 7.2, 0.09% sodium azide.
For research use only.

About AR / Androgen Receptor

P10275 NM_000044 NP_000035.2

AR Antibody, Androgen receptor Antibody, Dihydrotestosterone receptor Antibody, DHTR Antibody, AIS Antibody, KD Antibody, NR3C4 Antibody, HUMARA Antibody, SBMA Antibody, TFM Antibody, SMAX1 Antibody, HYSP1 Antibody

The androgen receptor (AR) is a NR3 Steroid Receptor located on the X chromosome. AR is a phosphoprotein and acts as a steroid hormone-activated transcription factor for androgen-responsive genes. Mutations in the AR gene are associated with androgen insensitivity syndrome (CAIS) or testicular feminization syndrome, Reifenstein syndrome, and Kennedy spinal and bulbar muscular atrophy. They lead to symptoms such as low virilization, reduced sperm production, testicular atrophy, and infertility.

Requested From: United States
Date Requested: 12/2/2016

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