Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG1,k) to Human APP / Beta Amyloid Precursor
IHC - Paraffin, ICC, Western blot, ELISA
Goat Polyclonal (IgG) to Human APP / Beta Amyloid Precursor
IHC - Paraffin, Western blot
Human APP / Beta Amyloid Precursor
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin (1:300)
Western blot (1:3000)
Specificity and Use
Synthetic peptide corresponding to amino acids 339-348 of the C-terminus of APP frameshift mutant.
Binds to the truncated amyloid precursor protein frameshift mutant, which results from a GA dinucleotide deletion from the normal APP gene. This abnormal protein has been found to accumulate in the brains of some patients with Alzheimer's disease. This reagent labels dystrophic neurites in senile plaques of brains from AD patients following formalin fixation.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP.