Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Mouse, Rat (tested or 100% immunogen sequence identity)
Guinea pig, Rabbit (at least 90% immunogen sequence identity)
Western blot (0.3 - 1 µg/ml)
IHC - Paraffin
Specificity and Use
ADRB1 antibody was raised against synthetic peptide ESDEARRCYNDPK from an internal region of human ADRB1 (NP_000675.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat (100%); Panda, Cat, Rabbit, Guinea pig (92%); Dog (85%).
LS-E26048 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C54455. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients. Wallukat G, Muoz Saravia SG, Haberland A, Bartel S, Araujo R, Valda G, Duchen D, Diaz Ramirez I, Borges AC, Schimke I. Journal of the American College of Cardiology. 2010 55:463-8.
Aptamer neutralization of beta1-adrenoceptor autoantibodies isolated from patients with cardiomyopathies. Haberland A, Wallukat G, Dahmen C, Kage A, Schimke I. Circulation research. 2011 109:986-92. (IP)
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.