ZP3

zona pellucida glycoprotein 3 (sperm receptor)

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.

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Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

ZP3 (8)

Publications

No (8)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

GST (2)

Myc-DDK (Flag) (4)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

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Human ZP3 Protein (Recombinant GST) (aa23-346) - LS-G22639

Source:

E. coli

Tag:

GST

Molecular Weight:

63.3 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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ZP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127018

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.1 kDa

Price:

100 µg/$494

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ZP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114824

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.1 kDa

Price:

100 µg/$494

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Human ZP3 Protein (Recombinant GST) (Full Length) - LS-G31001

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.98 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ZP3 Protein (Recombinant 6His-SUMO, N-terminus) (aa23-387) - LS-G56627

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ZP3 Protein (Recombinant 6His, N-terminus) (aa23-387) - LS-G57069

Source:

Mammalian Cells

Tag:

6His, N-terminus

Price:

100 µg/$1,009; 20 µg/$431; 1 mg/$3,451

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Human ZP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79683

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.1 kDa

Price:

20 µg/$150

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Human ZP3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79684

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.1 kDa

Price:

20 µg/$150

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