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ZNF385A / ZNF385

zinc finger protein 385A

RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.

Gene Name: zinc finger protein 385A
Family/Subfamily: Zinc Finger
Synonyms: ZNF385A, HZF, Zinc finger protein 385, Zinc finger protein 385A, ZFP385, ZNF385, Retinal zinc finger protein, RZF
Target Sequences: NM_015481 NP_056296.1 Q96PM9

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Products
Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
ZNF385A / ZNF385 (5)
No (5)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
ZNF385A / ZNF385 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.2 kDa
100 µg/$494
ZNF385A / ZNF385 Protein - 12.5% SDS-PAGE of human ZNF385 stained with Coomassie Blue
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Wheat Germ Extract
GST
64.7 kDa
10 µg/$479; 25 µg/$670
ZNF385A / ZNF385 Protein - Purified recombinant protein ZNF385A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
38.2 kDa
20 µg/$1,107
ZNF385A / ZNF385 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
38.2 kDa
20 µg/$150
ZNF385A / ZNF385 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Viewing 1-5 of 5 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).