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ZNF238

zinc finger and BTB domain containing 18

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.

Gene Name: zinc finger and BTB domain containing 18
Family/Subfamily: Zinc Finger
Synonyms: ZBTB18, 58 kDa repressor protein, C2H2-171, RP58, Transcriptional repressor RP58, Zinc finger protein 238, Zinc finger protein C2H2-171, TAZ-1, TAZ1, ZNF238
Target Sequences: NM_006352 NP_006343.2 Q99592

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
ZNF238 (5)
No (5)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
ZNF238 Protein - 12.5% SDS-PAGE of human ZNF238 stained with Coomassie Blue
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Wheat Germ Extract
GST
84.8 kDa
2 µg/$439
ZNF238 Protein - Purified recombinant protein ZBTB18 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
59.2 kDa
20 µg/$1,107
ZNF238 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ZNF238 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.2 kDa
20 µg/$215
ZNF238 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.2 kDa
100 µg/$710
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).