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ZNF10 / KOX1

zinc finger protein 10

ZNF10 / KOX1 contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.

Gene Name:	zinc finger protein 10
Family/Subfamily:	Zinc Finger
Synonyms:	ZNF10, KOX1, Zinc finger protein 10, Zinc finger protein 10 (KOX 1), Zinc finger protein KOX1
Target Sequences:	NM_015394 P21506 P21506

Publications (1)

Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Susanne Wegmann , Sarah L DeVos, Bryan Zeitler, Kimberly Marlen, Rachel E Bennett, Marta Perez-Rando, Danny MacKenzie, Qi Yu, Caitlin Commins, Riley N Bannon, Bianca T Corjuc, Alison Chase, Lisa Diez, Hoang-Oanh B Nguyen, Sarah Hinkley, Lei Zhang, Alicia Goodwin, Annemarie Ledeboer, Stephen Lam, Irina Ankoudinova, Hung Tran, Nicholas Scarlott, Rainier Amora, Richard Surosky, Jeffrey C Miller, Ashley B Robbins, Edward J Rebar, Fyodor D Urnov, Michael C Holmes, Amy M Pooler, Brigit Riley, H Steve. Science advances. 2021 Mar;7:eabe1611. [Full Text Article] [PubMed:33741591] [PMC:PMC7978433] Related Antibodies: LS-C374589.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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