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ZKSCAN3 / ZNF306
zinc finger with KRAB and SCAN domains 3
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.
| Gene Name: | zinc finger with KRAB and SCAN domains 3 |
| Family/Subfamily: | Zinc Finger |
| Synonyms: | ZKSCAN3, DJ874C20.1, DJ874C20.1., KIAA0426, Zfp-47, ZFP306, Zinc finger protein 309, ZNF306, ZNF309, ZSCAN13, ZSCAN35, ZF47, Zinc finger protein 306, Zinc finger protein zfp47, Zfp47, Zinc finger protein 47 homolog |
| Target Sequences: | U71601 AAB16813.1 |
Publications (1)
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