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Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
Gene Name: | zinc finger, CCCH-type with G patch domain |
Synonyms: | ZGPAT, DJ583P15.3, GPATC6, KIAA1847, RP4-583P15.3, ZC3HDC9, ZIP, ZC3H9, GPATCH6 |
Target Sequences: | NM_032527 CAC03670.1 Q8N5A5 |
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