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ZFYVE9 / SARA

zinc finger, FYVE domain containing 9

This gene encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this gene.

Gene Name: zinc finger, FYVE domain containing 9
Family/Subfamily: Zinc Finger
Synonyms: ZFYVE9, HSARA, Madh-interacting protein, Receptor activation anchor, SMADIP, MADHIP, Novel serine protease, NSP, SARA
Target Sequences: NM_004799 NP_004790.2 O95405

Publications (1)

1
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFß signaling. Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, Chang L, Martinez-Høyer S, Condorelli G, Boldin M, Deng Y, Umlandt P, Fuller M, Karsan A. Nature communications. 2018 June;9:2418. [Full Text Article] [PubMed:29925839] [PMC:PMC6010451] Related Antibodies: LS-C410575.

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Antibodies (7)
Primary (7)
ZFYVE9 / SARA (7)
Human (7)
Mouse (3)
Rat (2)
WB (7)
Flo (2)
ELISA (2)
IF (2)
IP (4)
Peptide-ELISA (1)
rabbit (7)
IgG (6)
polyclonal pc (7)
Unconjugated (7)
aa1-50 (1)
No (6)
Yes (1)
ZFYVE9 / SARA Antibody - Western blot analysis of extracts of various cell lines.
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ZFYVE9 / SARA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
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ZFYVE9 / SARA Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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ZFYVE9 / SARA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IP, WB
Unconjugated
100 µg/$341
Select
ZFYVE9 / SARA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IP, WB
Unconjugated
100 µg/$341
ZFYVE9 / SARA Antibody
Select
ZFYVE9 / SARA Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
50 µl/$286; 100 µl/$321
ZFYVE9 / SARA Antibody - Western blot analysis of ZFYVE9 using HeLa whole cells lysates
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ZFYVE9 / SARA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
ZFYVE9 / SARA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).