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ZFAND5
zinc finger, AN1-type domain 5
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
| Gene Name: | zinc finger, AN1-type domain 5 |
| Family/Subfamily: | Zinc Finger |
| Synonyms: | ZFAND5, AN1-type zinc finger protein 5, Zinc finger protein 216, Zinc finger, AN1-type domain 5, ZNF216, ZA20D2, ZFAND5A |
| Target Sequences: | NM_006007 NP_005998.1 O76080 |
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