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ZEB2 / SIP-1

zinc finger E-box binding homeobox 2

ZEB2 is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.

Gene Name: zinc finger E-box binding homeobox 2
Synonyms: ZEB2, KIAA0569, SIP1, SMADIP1, ZFX1B, SIP-1, SMAD interacting protein 1, Smad-interacting protein 1, ZFHX1B, Zinc finger homeobox 1b, HSPC082
Target Sequences: NM_014795 NP_055610.1 O60315

Publications (4)

1
miR-215 functions as a tumor suppressor and directly targets ZEB2 in human non-small cell lung cancer. Hou Y, Zhen J, Xu X, Zhen K, Zhu B, Pan R, Zhao C. Oncology letters. 2015 10:1985-1992. (WB; Human) [Full Text Article] [PubMed:26622784] [PMC:PMC4579799] Related Antibodies: LS-C160768.
2
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C160768.
3
Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro. Nevi L, Costantini D, Safarikia S, Di Matteo S, Melandro F, Berloco PB, Cardinale V. Cells. 2019 November;8:E1443. [Full Text Article] [PubMed:31731674] [PMC:PMC6912632]
4
A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration. Shanzheng Yang, Enrique M Toledo, Pedro Rosmaninho, Changgeng Peng, Per Uhlén, Diogo S Castro, Ernest Arenas. Communications biology. 2018 Jun;1:75. [Full Text Article] [PubMed:30271956] [PMC:PMC6123725]
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ELISA Kits (7)
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ZEB2 / SIP-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ZEB2 / SIP-1 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
ZEB2 / SIP-1 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
ZEB2 / SIP-1 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Mouse
13.72 - 10000 pg/ml
Chemiluminescent
Tissue Homogenates
1 Plate/$990
ZEB2 / SIP-1 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ZEB2 / SIP-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$854
ZEB2 / SIP-1 ELISA Kit
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DNA Binding
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$694
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).