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ZC3HC1 / NIPA

zinc finger, C3HC-type containing 1

Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

Gene Name:	zinc finger, C3HC-type containing 1
Synonyms:	ZC3HC1, HSPC216, HNIPA, Zinc finger, C3HC type 1, NIPA
Target Sequences:	NM_016478 NP_057562.3 Q86WB0

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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