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ZBTB7B / HcKrox
zinc finger and BTB domain containing 7B
Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes.
| Gene Name: | zinc finger and BTB domain containing 7B |
| Synonyms: | ZBTB7B, C-KROX, HcKROX, THPOK, ZFP-67, Zinc finger protein 67 homolog, Zinc finger protein Th-POK, ZNF857B, Zinc finger protein 857B, ZFP67, ZBTB15 |
| Target Sequences: | NM_015872 NP_056956.2 O15156 |
Publications (1)
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