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Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation.
Gene Name: | zinc finger and BTB domain containing 17 |
Synonyms: | ZBTB17, MIZ-1, MIZ1, Zinc finger protein 151, ZNF60, PHZ-67, Zinc finger protein 60, ZNF151 |
Target Sequences: | NM_003443 NP_003434.2 Q13105 |
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