XRCC5 / Ku80

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

XRCC5 / Ku80 (8)

Publications

No (8)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST (1)

His (2)

His-T7 (1)

MBP, N-terminus + 6His, C-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

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Human XRCC5 / Ku80 Protein (Recombinant His) (aa2-460) - LS-G25198

Source:

E. coli

Tag:

His

Molecular Weight:

55.7 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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Human XRCC5 / Ku80 Protein (Recombinant MBP, N-terminus + 6His, C-terminus) - LS-G136861

Source:

Baculovirus

Tag:

MBP, N-terminus + 6His, C-terminus

Molecular Weight:

67.4 kDa

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

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Human XRCC5 / Ku80 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) - LS-G137143

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

30.4 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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XRCC5 / Ku80 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110749

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.5 kDa

Price:

100 µg/$494

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Human XRCC5 / Ku80 Protein (Recombinant GST) (Full Length) - LS-G30920

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106.26 kDa

Price:

2 µg/$439

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Mouse XRCC5 / Ku80 Protein (Recombinant His-T7) (aa251-732) - LS-G25199

Source:

E. coli

Tag:

His-T7

Molecular Weight:

58.8 kDa

Price:

10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219

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Human XRCC5 / Ku80 Protein (Recombinant His) (aa251-455) - LS-G21330

Source:

E. coli

Tag:

His

Molecular Weight:

27.53 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human XRCC5 / Ku80 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74658

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.5 kDa

Price:

20 µg/$150

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