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WWP2

WW domain containing E3 ubiquitin protein ligase 2

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Gene Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: WWP2, AIP2, WW domain-containing protein 2, WWp2-like
Target Sequences: NM_007014 NP_008945.2 O00308

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Products
Proteins (11)
Over-Expression Lysate (4)
Recombinant (7)
WWP2 (11)
No (11)
GST (1)
GST, N-terminus (1)
His-GST (1)
His-T7, N-terminus (1)
Myc-DDK (Flag) (7)
Human (9)
293T Cells (2)
Baculovirus (1)
E. coli (1)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (1)
WWP2 Protein - 12.5% SDS-PAGE of human WWP2 stained with Coomassie Blue
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Wheat Germ Extract
GST
61.6 kDa
10 µg/$479; 25 µg/$670
WWP2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
WWP2 Protein - Purified recombinant protein WWP2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
98.7 kDa
20 µg/$1,107
WWP2 Protein - Purified recombinant protein WWP2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35.1 kDa
20 µg/$1,107
WWP2 Protein - Purified recombinant protein WWP2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
50.9 kDa
20 µg/$1,107
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Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
126.7 kDa
100 µg/$843
WWP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
98.7 kDa
20 µg/$150
WWP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
35.1 kDa
20 µg/$150
WWP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35.1 kDa
100 µg/$494
WWP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
98.7 kDa
100 µg/$494
WWP2 Protein - Recombinant WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) by SDS-PAGE
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E. coli
His-T7, N-terminus
35.9kDa
10 µg/$260; 50 µg/$335; 200 µg/$622; 100 µg/$497; 1 mg/$1,588; 500 µg/$1,185; 5 mg/$2,522; 2 mg/$1,760
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).