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WWP2
WW domain containing E3 ubiquitin protein ligase 2
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
| Gene Name: | WW domain containing E3 ubiquitin protein ligase 2 |
| Synonyms: | WWP2, AIP2, WW domain-containing protein 2, WWp2-like |
| Target Sequences: | NM_007014 NP_008945.2 O00308 |
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