WWP1

WW domain containing E3 ubiquitin protein ligase 1

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

WWP1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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WWP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114922

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

105 kDa

Price:

100 µg/$494

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Human WWP1 Protein (Recombinant GST, N-terminus) (aa152-260) - LS-G61727

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human WWP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81986

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

105 kDa

Price:

20 µg/$150

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