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WT1 / Wilms Tumor 1

Wilms tumor 1

WT1 / Wilms Tumor 1 is a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

Gene Name: Wilms tumor 1
Synonyms: WT1, GUD, EWS-WT1, Amino-terminal domain of EWS, WAGR, WIT-2, Wilms tumor protein, AWT1, Wilms tumor 1, WT33, NPHS4, WT-1
Target Sequences: NM_024426 NP_077744.3 P19544

Publications (5)

1
Characterization of monoclonal antibodies directed to the amino-terminus of the WT1, Wilms' tumor suppressor protein. Rauscher FJ, Morris JF, Fredericks WJ, Lopez-Guisa J, Balakrishnan C, Jost M, Herlyn M, Rodeck U. Hybridoma. 1998 17:191-8. [PubMed:9627060]
2
WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia. McCarty G, Awad O, Loeb DM. The Journal of biological chemistry. 2011 286:43634-43. [PubMed:22030397] [PMC:PMC3243556]
3
Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Musah S, , Mammoto A, Ferrante TC, Jeanty SSF, Hirano-Kobayashi M, Mammoto T, Roberts K, Chung S, Novak R, Ingram M, Fatanat-Didar T, Koshy S, Weaver JC, Church GM, , Ingber DE, ,. Nature biomedical engineering. 2017 1: (IHC; Human) [Full Text Article] [PubMed:29038743] Related Antibodies: LS-C224662.
4
Glomerular Aging and Focal Global Glomerulosclerosis: A Podometric Perspective. Hodgin JB, Bitzer M, Wickman L, Afshinnia F, Wang SQ, O'Connor C, Yang Y, Meadowbrooke C, Chowdhury M, Kikuchi M, Wiggins JE, Wiggins RC. Journal of the American Society of Nephrology : JASN. 2015 26:3162-78. (WB; Human) [Full Text Article] [PubMed:26038526]
5
Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip. Samira Musah, Nikolaos Dimitrakakis, Diogo M Camacho, George M Church, Donald E Ingber. Nature protocols. 2018 Jul;13:1662-1685. [Full Text Article] [PubMed:29995874] [PMC:PMC6701189] Related Antibodies: LS-C224662.
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WT1 / Wilms Tumor 1 (89)
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WT1 / Wilms Tumor 1 Antibody - Anti-WT1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Cancer Pathology
Cancer
WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (1E9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$485
WT1 / Wilms Tumor 1 Antibody - Anti-WT1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa396-448) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
WT1 / Wilms Tumor 1 Antibody - Anti-WT1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Mouse, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
WT1 / Wilms Tumor 1 Antibody - Anti-WT1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
WT1 / Wilms Tumor 1 Antibody - Anti-WT1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Xenopus, Chicken, Rabbit, Mouse, Dog, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
WT1 / Wilms Tumor 1 Antibody - WT1 Antibody (Center E361) immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (Concentrated) (6F-H2) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$840
WT1 / Wilms Tumor 1 Antibody - Western blot analysis of extracts of various cell lines, using WT1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (N-Terminus) (6F-H2) Antibody
Human
IHC, IHC-P
Unconjugated
0.1 ml/$284; 0.5 ml/$500; 1 ml/$735
WT1 / Wilms Tumor 1 Antibody - IHC testing of formalin-fixed, paraffin-embedded human kidney stained with WT1 antibody (clone RMWT1-1).
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WT1 / Wilms Tumor 1 Rabbit anti-Human Monoclonal (RMWT1-1) Antibody
Human
IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
WT1 / Wilms Tumor 1 Antibody - IHC testing of formalin-fixed, paraffin-embedded human kidney stained with WT1 antibody (clone RMWT1-1). This image was taken for the unmodified form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Rabbit anti-Human Monoclonal (Azide-free, BSA-free) (RMWT1-1) Antibody
Human
IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (Biotin) Antibody
Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (FITC) Antibody
Human
ELISA, Flo, IF, IHC, WB
FITC Conjugated
200 µl/$952
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (APC) Antibody
Human
FLISA, IF, IHC, WB
APC Conjugated
200 µl/$952
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (PE) Antibody
Human
ELISA, IF, IHC, WB
PE Conjugated
200 µl/$952
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WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
WT1 / Wilms Tumor 1 Antibody - IHC testing of formalin-fixed, paraffin-embedded human kidney stained with WT1 antibody (clone WT1/857). This image was taken for the unmodified form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (Ready-to-Use) (WT1/857) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
WT1 / Wilms Tumor 1 Antibody - Detection of WT1 in 293 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (6F-H2) Antibody
Human
IHC, IP, WB
Unconjugated
0.1 ml/$386
WT1 / Wilms Tumor 1 Antibody - Detection of WT1 in 293 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (Biotin) (6F-H2) Antibody
Human
IHC, IP, WB
Biotin Conjugated
0.1 ml/$416
WT1 / Wilms Tumor 1 Antibody - Detection of WT1 in 293 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (DY650) (6F-H2) Antibody
Human
IHC, IP, WB
DY650 Conjugated
0.1 ml/$416
WT1 / Wilms Tumor 1 Antibody - Detection of WT1 in 293 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (DY488) (6F-H2) Antibody
Human
IHC, IP, WB
DY488 Conjugated
0.1 ml/$416
WT1 / Wilms Tumor 1 Antibody - Formalin-fixed, paraffin-embedded human fetal kidney stained with Wilms Tumor 1 antibody (6F-H2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (Azide-free, BSA-free) (6F-H2) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
WT1 / Wilms Tumor 1 Antibody - Formalin-fixed, paraffin-embedded human fetal kidney stained with Wilms Tumor 1 antibody (6F-H2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (Ready-to-Use) (6F-H2) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
WT1 / Wilms Tumor 1 Antibody - IHC testing of formalin-fixed, paraffin-embedded human kidney stained with Wilms Tumor 1 antibody (clone SPM361).
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WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (SPM361) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).