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Werner syndrome, RecQ helicase-like

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.

Gene Name: Werner syndrome, RecQ helicase-like
Synonyms: WRN, Exonuclease WRN, RecQ protein-like 2, RECQL2, RECQL3, Werner syndrome, RECQ3, DNA helicase, RecQ-like type 3
Target Sequences: NM_000553 NP_000544.2 Q14191

Filtered by: None
Over-Expression Lysate (1)
Recombinant (1)
WRN (2)
GST,N-terminus (1)
Myc + DDK (1)
Human (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
No (2)
Showing 1-2 of 2 results

Human WRN Protein (Recombinant GST,N-terminus) (aa1322-1432) - LS-G60529
Wheat Germ Extract
2µg  $385.00
12.5% SDS-PAGE Stained with Coomassie Blue.

WRN Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G123114
HEK 293 Cells
Myc + DDK
162.3 kDa
100µg  $475.00
Showing 1-2 of 2 results


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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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