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WNT16

wingless-type MMTV integration site family, member 16

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.

Gene Name: wingless-type MMTV integration site family, member 16
Family/Subfamily: WNT , not assigned-WNT
Synonyms: WNT16, Protein Wnt-16
Target Sequences: NM_016087 NP_057171.2 Q9UBV4

Publications (5)

1
Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2. Howard EW, Been LF, Lerner M, Brackett D, Lightfoot S, Bullen EC, Sanghera DK. BMC genetics. 2013 14:28. (IHC; Human) [Full Text Article] [PubMed:23617586] [PMC:PMC3675375] Related Antibodies: LS-A9630.
2
Development of a peptide-siRNA nanocomplex targeting NF- ?B for efficient cartilage delivery. Yan H, Duan X, Pan H, Akk A, Sandell LJ, Wickline SA, Rai MF, Pham CTN. Scientific reports. 2019 January;9:442. [Full Text Article] [PubMed:30679644] [PMC:PMC6345850] Related Antibodies: LS-A9629.
3
Induction of WNT16 via Peptide-mRNA Nanoparticle-Based Delivery Maintains Cartilage Homeostasis. Huimin Yan, Ying Hu, Antonina Akk, Muhammad Farooq Rai, Hua Pan, Samuel A Wickline, Christine T N Pham. Pharmaceutics. 2020 Jan;12:73. [Full Text Article] [PubMed:31963412] [PMC:PMC7022671] Related Antibodies: LS-A9629.
4
WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Binet R, Ythier D, Robles AI, Collado M, Larrieu D, Fonti C, Brambilla E, Brambilla C, Serrano M, Harris CC, Pedeux R. Cancer research. 2009 Dec;69:9183-91. [Full Text Article] [PubMed:19951988] Related Antibodies: LS-A9630.
5
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Wiel C, Augert A, Vincent DF, Gitenay D, Vindrieux D, Le Calv[Character e9] B, Arfi V, Lallet-Daher H, Reynaud C, Treilleux I, Bartholin L, Lelievre E, Bernard D. Cell death & disease. 2013 4:e855. [Full Text Article] [PubMed:24113189] [PMC:PMC3824691] Related Antibodies: LS-A9630.
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Proteins (6)
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WNT16 (6)
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WNT16 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
37.6 kDa
100 µg/$494
WNT16 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.5 kDa
100 µg/$494
WNT16 Protein - Recombinant  Wingless Type MMTV Integration Site Family, Member 16 By SDS-PAGE
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E. coli
His-GST
70.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
WNT16 Protein - Purified recombinant protein WNT16 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
37.6 kDa
20 µg/$1,107
WNT16 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.5 kDa
20 µg/$150
WNT16 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
37.6 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).